Anti-BTK抗体(ab25971)

概述

• 产品名称Anti-BTK抗体
  参阅全部 BTK 一抗
• 描述
  兔多克隆抗体to BTK
• 经测试应用适用于: WB, IHC-P, ICC/IFmore details
• 种属反应性
  与反应: Mouse, Human
  
• 免疫原

  Synthetic peptide, corresponding to 16 N terminal amino acids near the amino terminus of Human BTK.

• 阳性对照
  • U937 cell lysate.

性能

• 形式Liquid
• 存放说明Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C. Avoid freeze / thaw cycle. Stable for 12 months at -20°C.
• 存储溶液Preservative: 0.02% Sodium Azide.
  Constituents: PBS.
• Concentration information loading...
• 纯度Immunogen affinity purified
• 纯化说明BTK Antibody is affinity chromatography purified via peptide column.
• 克隆多克隆
• 同种型IgG
• 研究领域
  • Signal Transduction
  • Protein Phosphorylation
  • Tyrosine Kinases
  • Other

  • Immunology
  • Innate Immunity
  • TLR Signaling

相关产品

• Compatible Secondaries
  • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
  • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)
• Immunizing Peptide (Blocking)
  • Human BTK peptide (ab39736)
• Positive Controls
  • U937 cytoplasmic extract lysate (ab14904)

应用

靶标

• 功能Plays a crucial role in B-cell ontogeny. Transiently phosphorylates GTF2I on tyrosine residues in response to B-cell receptor cross-linking. Required for the formation of functional ARID3A DNA-binding complexes.
• 疾病相关Defects in BTK are the cause of X-linked agammaglobulinemia (XLA) [MIM:300755]; also known as X-linked agammaglobulinemia type 1 (AGMX1) or immunodeficiency type 1 (IMD1). XLA is a humoral immunodeficiency disease which results in developmental defects in the maturation pathway of B-cells. Affected boys have normal levels of pre-B-cells in their bone marrow but virtually no circulating mature B-lymphocytes. This results in a lack of immunoglobulins of all classes and leads to recurrent bacterial infections like otitis, conjunctivitis, dermatitis, sinusitis in the first few years of life, or even some patients present overwhelming sepsis or meningitis, resulting in death in a few hours. Treatment in most cases is by infusion of intravenous immunoglobulin.
  Defects in BTK may be the cause of X-linked hypogammaglobulinemia and isolated growth hormone deficiency (XLA-IGHD) [MIM:307200]; also known as agammaglobulinemia and isolated growth hormone deficiency or Fleisher syndrome or isolated growth hormone deficiency type 3 (IGHD3). In rare cases XLA is inherited together with isolated growth hormone deficiency (IGHD).
• 序列相似性Belongs to the protein kinase superfamily. Tyr protein kinase family. TEC subfamily.
  Contains 1 Btk-type zinc finger.
  Contains 1 PH domain.
  Contains 1 protein kinase domain.
  Contains 1 SH2 domain.
  Contains 1 SH3 domain.
• 翻译后修饰Autophosphorylated on Tyr-223 and Tyr-551. Phosphorylation of Tyr-223 may create a docking site for a SH2 containing protein.
• 细胞定位Cytoplasm. Membrane. Nucleus.

• Target information above from: UniProt accession Q06187 The UniProt Consortium
  The Universal Protein Resource (UniProt) in 2010
  Nucleic Acids Res. 38:D142-D148 (2010) .

  Information by UniProt
• 数据库链接
  • Entrez Gene: 695 Human
  • Entrez Gene: 12229 Mouse
  • Omim: 300300 Human
  • SwissProt: Q06187 Human
  • SwissProt: P35991 Mouse
  • Unigene: 159494 Human
  • Unigene: 4475 Mouse
• 别名
  • Agammaglobulinaemia tyrosine kinase antibody
  • AGMX 1 antibody
  • AGMX1 antibody

  • AT antibody
  • ATK antibody
  • B cell progenitor kinase antibody
  • B-cell progenitor kinase antibody
  • BPK antibody
  • Bruton agammaglobulinemia tyrosine kinase antibody
  • Bruton tyrosine kinase antibody
  • Bruton’s Tyrosine Kinase antibody
  • Btk antibody
  • BTK_HUMAN antibody
  • dominant-negative kinase-deficient Brutons tyrosine kinase antibody
  • IMD 1 antibody
  • IMD1 antibody
  • MGC126261 antibody
  • MGC126262 antibody
  • OTTHUMP00000063593 antibody
  • PSCTK 1 antibody
  • PSCTK1 antibody
  • truncated Bruton agammaglobulinemia tyrosine kinase antibody
  • Tyrosine protein kinase BTK antibody
  • Tyrosine-protein kinase BTK antibody
  • tyrosine-protein kinase BTK isoform (lacking exon 14 antibody
  • XLA antibody

  see all