概述

  • 产品名称Anti-BSND抗体
    参阅全部 BSND 一抗
  • 描述
    小鼠多克隆抗体to BSND
  • 经测试应用适用于: WB, IHC-Pmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Full length protein, corresponding to amino acids 1-320 of Human BSND (NP_476517.1)

  • 阳性对照
    • 293 cell lysate Transfected 293T cell lysate Human kidney tissue

性能

应用

Our Abpromise guarantee covers the use of ab88518 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 35 kDa.
IHC-P Use a concentration of 3 µg/ml.

靶标

  • 功能Functions as a beta-subunit for CLCNKA and CLCNKB chloride channels. In the kidney CLCNK/BSND heteromers mediate chloride reabsorption by facilitating its basolateral efflux. In the stria, CLCNK/BSND channels drive potassium secretion by recycling chloride for the basolateral SLC12A2 cotransporter.
  • 组织特异性Expressed primarily in kidney. Expressed in specific nephron segments and in the stria vascularis of the inner ear.
  • 疾病相关Bartter syndrome 4A
  • 细胞定位Cell membrane. Cytoplasm. A significant amount also observed intracellularly. Staining in membranes of the renal tubule and of potassium-secreting epithelia of the inner ear is basolateral.
  • Information by UniProt
  • 数据库链接
  • 别名
    • BART antibody
    • Bartter syndrome infantile with sensorineural deafness antibody
    • Bartter syndrome, infantile, with sensorineural deafness (Barttin) antibody
    • Barttin antibody
    • Bsnd antibody
    • BSND_HUMAN antibody
    • deafness, autosomal recessive 73 antibody
    • DFNB 73 antibody
    • DFNB73 antibody
    see all

Anti-BSND antibody 图像

  • Anti-BSND antibody (ab88518) at 1 µg/ml + 293 cell lysate at 50 µg

    Secondary
    Goat anti-mouse IgG at 1/5000 dilution

    Predicted band size : 35 kDa
  • All lanes : Anti-BSND antibody (ab88518) at 1 µg/ml

    Lane 1 : BSND transfected 293T cell lysate
    Lane 2 : Untransfected 293T cell lysate

    Lysates/proteins at 25 µg per lane.

    Secondary
    Goat anti-mouse IgG at 1/5000 dilution

    Predicted band size : 35 kDa
    Observed band size : 35 kDa
  • Immunoperoxidase staining of human kidney tissue labelled with ab88518 at 3 µg/ml

Anti-BSND antibody (ab88518)参考文献

ab88518 has not yet been referenced specifically in any publications.

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