概述

  • 产品名称Anti-BRIT1抗体
    参阅全部 BRIT1 一抗
  • 描述
    小鼠单克隆抗体to BRIT1
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Recombinant fragment: ATSSCVTSAP EEALRCCRQA GKEDACPEGN GFSYTIEDPA LPKGHDDDLT PLEGSLEEMK EAVGLKSTQN KGTTSKISNS SEGEAQSEH, corresponding to amino acids 399-488 of Human BRIT1

性能

应用

Our Abpromise guarantee covers the use of ab57751 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB
  • 应用说明WB: Use at a concentration of 1-5 µg/ml.

    This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Implicated in chromosome condensation and DNA damage induced cellular responses. May play a role in neurogenesis and regulation of the size of the cerebral cortex.
    • 组织特异性Expressed in fetal brain, liver and kidney.
    • 疾病相关Defects in MCPH1 are the cause of microcephaly primary type 1 (MCPH1) [MIM:251200]; also known as true microcephaly or microcephaly vera. Microcephaly is defined as a head circumference more than 3 standard deviations below the age-related mean. Brain weight is markedly reduced and the cerebral cortex is disproportionately small. Despite this marked reduction in size, the gyral pattern is relatively well preserved, with no major abnormality in cortical architecture. Primary microcephaly is further defined by the absence of other syndromic features or significant neurological deficits. This entity is inherited as autosomal recessive trait.
    • 序列相似性Contains 3 BRCT domains.
    • 细胞定位Cytoplasm > cytoskeleton > centrosome.
    • Information by UniProt
    • 数据库链接
    • 别名
      • BRCT repeat inhibitor of TERT expression 1 antibody
      • BRIT 1 antibody
      • FLJ12847 antibody
      • Hypothetical protein FLJ12847 antibody
      • MCPH 1 antibody
      • MCPH1 antibody
      • MCPH1_HUMAN antibody
      • MCT antibody
      • Microcephalin 1 antibody
      • Microcephalin antibody
      • Microcephaly primary autosomal recessive 1 antibody
      see all

    Anti-BRIT1 antibody 图像

    • Western blot against tagged recombinant protein immunogen using ab57751 BRIT1 antibody at 1ug/ml. Predicted band size of immunogen is 36 kDa

    Anti-BRIT1 antibody (ab57751)参考文献

    ab57751 has not yet been referenced specifically in any publications.

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