概述

  • 产品名称
  • 描述
    兔多克隆抗体to BRIT1
  • 经测试应用
    适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide conjugated to KLH, corresponding to a region within N terminal amino acids 103-133 of Human BRIT1 (NP_078872.2, NP_001166045.1).

  • 阳性对照
    • HL60 cell line lysate.

性能

应用

Our Abpromise guarantee covers the use of ab123361 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/100 - 1/500. Predicted molecular weight: 93 kDa.

靶标

  • 功能
    Implicated in chromosome condensation and DNA damage induced cellular responses. May play a role in neurogenesis and regulation of the size of the cerebral cortex.
  • 组织特异性
    Expressed in fetal brain, liver and kidney.
  • 疾病相关
    Defects in MCPH1 are the cause of microcephaly primary type 1 (MCPH1) [MIM:251200]; also known as true microcephaly or microcephaly vera. Microcephaly is defined as a head circumference more than 3 standard deviations below the age-related mean. Brain weight is markedly reduced and the cerebral cortex is disproportionately small. Despite this marked reduction in size, the gyral pattern is relatively well preserved, with no major abnormality in cortical architecture. Primary microcephaly is further defined by the absence of other syndromic features or significant neurological deficits. This entity is inherited as autosomal recessive trait.
  • 序列相似性
    Contains 3 BRCT domains.
  • 细胞定位
    Cytoplasm > cytoskeleton > centrosome.
  • Information by UniProt
  • 数据库链接
  • 别名
    • BRCT repeat inhibitor of TERT expression 1 antibody
    • BRIT 1 antibody
    • FLJ12847 antibody
    • Hypothetical protein FLJ12847 antibody
    • MCPH 1 antibody
    • MCPH1 antibody
    • MCPH1_HUMAN antibody
    • MCT antibody
    • Microcephalin 1 antibody
    • Microcephalin antibody
    • Microcephaly primary autosomal recessive 1 antibody
    see all

图片

  • Anti-BRIT1 antibody (ab123361) at 1/100 dilution + HL60 cell line lysate at 35 µg

    Predicted band size : 93 kDa

实验方案

文献

This product has been referenced in:
  • Zhou L  et al. Overexpression of MCPH1 inhibits uncontrolled cell growth by promoting cell apoptosis and arresting the cell cycle in S and G2/M phase in lung cancer cells. Oncol Lett 11:365-372 (2016). Read more (PubMed: 26870219) »

See 1 Publication for this product

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