概述

  • 产品名称
    Brilliant Blue G
  • 描述
    Potent, noncompetitive P2X7 antagonist
  • 别名
    • Acid blue 90
    • Coomassie® Brilliant Blue G
  • 生物学描述
    Potent, non-competitive antagonist of rat and human P2X7 receptors (IC50 values are 10 and 200 nM, respectively). Displays >1000-fold selectivity over P2X4. IC50 values for inhibition of the other P2X receptors range from 2 to >30 µM. Rat and human P2X4 receptors show IC50 values of >10 and 3.2 µM, respectively.

性能

  • 化学名称
    N-[4-[[4-[(4-Ethoxyphenyl)amino]phenyl][4-[ethyl[(3-sulfophenyl)methyl]amino]-2-methylphenyl]methylene]-3-methyl-2,5-cyclohexadien-1-ylidene]-N-ethyl-3-sulfobenzenemethanaminium , inner salt, sodium salt
  • 分子量
    854.02
  • 化学结构
    Chemical Structure
  • 分子式
    C47H48N3NaO7S2
  • CAS编号
    6104-58-1
  • PubChem识别号
    61363
  • 存放说明
    Store at Room Temperature. The product can be stored for up to 12 months.
  • 溶解度概述
    Soluble in water to 50 mM
  • 处理

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES
    CC/[N+](Cc1cccc(c1)S([O-])(=O)=O)=C2/C=C/C(C(C)=C2)=C(/c4ccc(Nc3ccc(OCC)cc3)cc4)c5ccc(cc5C)N(Cc6cccc(c6)S(=O)(=O)O[Na])CC
  • 来源

    Synthetic

  • 研究领域

文献

This product has been referenced in:
  • Ryu JK & McLarnon JG Block of purinergic P2X(7) receptor is neuroprotective in an animal model of Alzheimer's disease. Neuroreport 19:1715-9 (2008). Read more (PubMed: 18852683) »
  • Michel AD  et al. Direct labelling of the human P2X7 receptor and identification of positive and negative cooperativity of binding. Br J Pharmacol 151:103-14 (2007). Read more (PubMed: 17339830) »
  • Jiang LH  et al. Brilliant blue G selectively blocks ATP-gated rat P2X(7) receptors. Mol Pharmacol 58:82-8 (2000). Read more (PubMed: 10860929) »

See 0 Publications for this product

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