概述

  • 产品名称Anti-BRD8抗体
    参阅全部 BRD8 一抗
  • 描述
    兔多克隆抗体to BRD8
  • 经测试应用适用于: IHC-Pmore details
  • 种属反应性
    与反应: Human
    预测可用于: Rat, Rabbit, Horse, Guinea pig, Dog, Pig, Rhesus monkey, Gorilla, Opossum, Chinese Hamster, Elephant
  • 免疫原

    Synthetic peptide corresponding to a region between residuse 200 and 250 of human BRD8 (Q969M9).

  • 阳性对照
    • Human prostate adenocarcinoma tissue.

性能

应用

Our Abpromise guarantee covers the use of ab84100 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P
  • 应用说明IHC-P: 1/100 - 1/500. Epitope exposure with citrate buffer will enhance staining.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 相关性BRD8 may act as a coactivator during transcriptional activation by hormone-activated nuclear receptors (NR). Isoform 2 stimulates transcriptional activation by AR/DHTR, ESR1/NR3A1, RXRA/NR2B1 and THRB/ERBA2. At least isoform 1 and isoform 2 are components of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. It interacts with MYC and adenovirus E1A protein.
    • 细胞定位Nuclear
    • 数据库链接
    • 别名
      • Bromodomain containing 8 antibody
      • p120 antibody
      • Skeletal muscle abundant protein antibody
      • Skeletal muscle abundant protein 2 antibody
      • SMAP antibody
      • SMAP2 antibody
      • Thyroid hormone receptor coactivating protein 120kDa antibody
      • Thyroid hormone receptor coactivating protein antibody
      see all

    Anti-BRD8 antibody 图像

    • ab84100 at 1/100 dilution staining BRD8 in human prostate adenocarcinoma by Immunohistochemistry, Formalin-fixed, Paraffin-embedded tissue. Detection: DAB staining.
    • ab84100 at 1/100 dilution staining BRD8 in human prostate adenocarcinoma by Immunohistochemistry, Formalin-fixed, Paraffin-embedded tissue. Detection: DAB staining.

    Anti-BRD8 antibody (ab84100)参考文献

    ab84100 has not yet been referenced specifically in any publications.

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