Anti-BPTF / FALZ抗体(ab99399)

概述

  • 产品名称
    Anti-BPTF / FALZ抗体
    参阅全部 BPTF / FALZ 一抗
  • 描述
    兔多克隆抗体to BPTF / FALZ
  • 经测试应用
    适用于: IHC-Pmore details
  • 种属反应性
    与反应: Human
    预测可用于: Chimpanzee, Orangutan
  • 免疫原

    Synthetic peptide, corresponding to a region within amino acids 1350-1400 of Human BPTF/ FALZ (NP_872579.2).

  • 阳性对照
    • Human Breast Carcinoma, Colon Carcinoma, Ovarian Carcinoma, Prostate Carcinoma and Testicular Seminoma tissues.

性能

应用

Our Abpromise guarantee covers the use of ab99399 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P 1/100 - 1/500. Epitope exposure is recommended. Epitope exposure with tris-EDTA pH9.0 buffer will enhance staining.

靶标

  • 功能
    Histone-binding component of NURF (nucleosome-remodeling factor), a complex which catalyzes ATP-dependent nucleosome sliding and facilitates transcription of chromatin. Specifically recognizes H3 tails trimethylated on 'Lys-4' (H3K4me3), which mark transcription start sites of virtually all active genes. May also regulate transcription through direct binding to DNA or transcription factors.
  • 组织特异性
    Ubiquitously expressed, with highest levels in testis. Present in kidney, liver and brain. In the brain, highest levels are found in motor cortex (at protein level).
  • 序列相似性
    Belongs to the PBTF family.
    Contains 1 bromo domain.
    Contains 1 DDT domain.
    Contains 2 PHD-type zinc fingers.
  • 发展阶段
    Abundantly expressed in the fetal brain. Present throughout the gray and white matter of the developing spinal cord at 18-22 gestational weeks. Expressed at low levels in adult brain and spinal cord and reexpressed in neurodegenerative diseases (at protein level).
  • 结构域
    The second PHD-type zinc finger mediates binding to histone H3K4Me3. Has specificity for trimethyllysine; introducing a mutation in the Tyr-2876 residue can induce binding to dimethyllysine.
  • 翻译后修饰
    Phosphorylation enhances DNA-binding.
    Highly susceptible to proteolysis.
  • 细胞定位
    Cytoplasm. Nucleus. In brains of Alzheimer disease patients, present in a subset of amyloid-containing plaques.
  • Information by UniProt
  • 数据库链接
  • 别名
    • BPTF antibody
    • BPTF_HUMAN antibody
    • Bromodomain and PHD finger containing transcription factor antibody
    • Bromodomain and PHD finger-containing transcription factor antibody
    • Bromodomain PHD finger transcription factor antibody
    • FAC 1 antibody
    • fac1 antibody
    • FALZ antibody
    • Fetal Alz 50 clone 1 protein antibody
    • Fetal Alz 50 reactive clone 1 antibody
    • Fetal Alz-50 clone 1 protein antibody
    • Fetal Alzheimer antigen antibody
    • Nucleosome remodeling factor antibody
    • Nucleosome remodeling factor subunit BPTF antibody
    • Nucleosome remodeling factor, large subunit antibody
    • Nucleosome-remodeling factor subunit BPTF antibody
    • NURF 301 antibody
    • NURF301 antibody
    see all

Anti-BPTF / FALZ antibody 图像

  • ab99399, at 1/250 dilution, staining BPTF / FALZ in formalin-fixed, paraffin-embedded Human breast carcinoma by Immunohistochemistry. Detection: DAB staining.
  • ab99399, at 1/250 dilution, staining BPTF / FALZ in formalin-fixed, paraffin-embedded Human colon carcinoma by Immunohistochemistry. Detection: DAB staining.

Anti-BPTF / FALZ antibody (ab99399)参考文献

ab99399 has not yet been referenced specifically in any publications.

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