Anti-BNP/ProBNP抗体(ab105181)

概述

  • 产品名称Anti-BNP/ProBNP抗体
    参阅全部 BNP/ProBNP 一抗
  • 描述
    兔多克隆抗体to BNP/ProBNP
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide conjugated to KLH derived from within residues 100 to the C-terminus of Human BNP/ProBNP.

  • 阳性对照
    • This antibody gave a positive signal in Human Heart tissue lysate.

性能

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应用

Our Abpromise guarantee covers the use of ab105181 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Detects a band of approximately 18 kDa (predicted molecular weight: 15 kDa).

靶标

  • 功能Cardiac hormone which may function as a paracrine antifibrotic factor in the heart. Also plays a key role in cardiovascular homeostasis through natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3.
  • 组织特异性Brain and also in atria, but at much lower levels than ANP.
  • 序列相似性Belongs to the natriuretic peptide family.
  • 翻译后修饰The brain natriuretic peptide 32 form is cleaved at Pro-104 by the prolyl endopeptidase FAP (seprase) activity (in vitro).
  • 细胞定位Secreted.
  • Information by UniProt
  • 数据库链接
  • 别名
    • ANFB_HUMAN antibody
    • BNP antibody
    • BNP(1-32) antibody
    • BNP(5-29) antibody
    • BNP-32 antibody
    • Brain type natriuretic peptide antibody
    • Gamma brain natriuretic peptide antibody
    • Gamma-brain natriuretic peptide antibody
    • Natriuretic peptide B antibody
    • Natriuretic peptide precursor B antibody
    • Natriuretic protein antibody
    • nppb antibody
    see all

Anti-BNP/ProBNP antibody 图像

  • All lanes : Anti-BNP/ProBNP antibody (ab105181) at 1 µg/ml

    Lane 1 : Human heart tissue lysate - total protein (ab29431)
    Lane 2 : Human heart tissue lysate - total protein (ab29431) with Immunising peptide at 1 µg/ml

    Lysates/proteins at 10 µg per lane.

    Secondary
    Goat Anti-Rabbit IgG H&L (HRP) preadsorbed (ab97080) at 1/5000 dilution
    Developed using the ECL technique

    Performed under reducing conditions.

    Predicted band size : 15 kDa
    Observed band size : 18 kDa (why is the actual band size different from the predicted?)
    Additional bands at : 108 kDa,73 kDa. We are unsure as to the identity of these extra bands.

    Exposure time : 6 minutes

Anti-BNP/ProBNP antibody (ab105181)参考文献

ab105181 has not yet been referenced specifically in any publications.

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