概述

  • 产品名称Anti-BNP抗体[24C5] (HRP)
    参阅全部 BNP 一抗
  • 描述
    小鼠单克隆抗体[24C5] to BNP (HRP)
  • 偶联物HRP
  • 特异性MAb 1B6 recognizes proBNP in Western Blotting after tricine-SDS-gel electrophoresis in reducing conditions.
  • 经测试应用适用于: Sandwich ELISA, WB, ELISAmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide:

    FGRKMDRISSSS

    , corresponding to N terminal amino acids 11-22 of Human BNP

  • 常规说明Immunoglobulin concentrations vary from batch to batch (generally 5-8 mg/ml for this clone). Please contact technical services for the latest information.

性能

应用

Our Abpromise guarantee covers the use of ab14699 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
Sandwich ELISA
WB
ELISA
  • 应用说明ELISA: Use at an assay dependent dilution.
    sELISA: Use at an assay dependent dilution.
    Can be paired for ELISA with Mouse monoclonal [50E1] to BNP (ab20984).

    WB: Use at an assay dependent dilution. Predicted molecular weight: 16 kDa.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 相关性Brain natriuretic peptide (BNP) circulates in blood as a peptide hormone with natriuretic, vasodilatory and renin inhibitory properties. BNP is secreted predominantly by the left ventricular myocytes in response to volume expansion and pressure overload. BNP belongs to a family of structurally similar peptide hormones, which includes atrial natriuretic peptide (ANP), BNP, C type natriuretic peptide (CNP) and urodilatin. These peptides are characterized by a common 17 amino acid ring structure with a disulfide bond between two cystein residues. This ring structure shows high homology between different natriuretic peptides (eleven of the 17 amino acid residues are homologous in the ring of each of the natriuretic peptides). BNP is a 32 amino acid peptide with disulfide bond between the cysteine residues Cys10 and Cys26. In earlier studies it has been demonstrated that BNP concentration in blood increases with the severity of congestive heart failure. Quantitative measurement of BNP in blood provides an objective indicator of congestive heart failure severity.
    • 细胞定位Secreted
    • 数据库链接
    • 别名
      • BNP(1-28) antibody
      • BNP(1-29) antibody
      • BNP(1-30) antibody
      • BNP(1-32) antibody
      • BNP(2-31) antibody
      • BNP(3-29) antibody
      • BNP(3-30) antibody
      • BNP(3-32) antibody
      • BNP(4-27) antibody
      • BNP(4-29) antibody
      • BNP(4-30) antibody
      • BNP(4-31) antibody
      • BNP(4-32) antibody
      • BNP(5-29) antibody
      • BNP(5-31) antibody
      • BNP(5-32) antibody
      • Brain natriuretic peptide 32 antibody
      • Brain type natriuretic peptide antibody
      • Gamma brain natriuretic peptide antibody
      • Natriuretic peptide B antibody
      • Natriuretic peptide precursor B antibody
      • natriuretic peptide, brain type antibody
      • Natriuretic peptides B antibody
      • natriuretic protein antibody
      • NPPB antibody
      see all

    Anti-BNP antibody [24C5] (HRP) (ab14699)参考文献

    This product has been referenced in:
    • Ding YD  et al. A sandwich ELISA for assessment of pharmacokinetics of HSA-(BNP)2 fusion protein in mouse plasma. J Pharm Biomed Anal 51:658-63 (2010). ELISA . Read more (PubMed: 19836183) »

    See 1 Publication for this product

    Product Wall

    Thank you for your email. For ab13111, the concentration of the batch that is currently in stock is 4.7 mg/ml. For ab14699, the concentration of the batch that is currently in stock is 5.80 mg/ml. If you have any additional questions, please contac...

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    Thank you for your enquiry. Thank you for your enquiry. All the information we have on species cross reactivity is specified on the datasheet, these are updated as soon as any new information is brought to our attention. As far as we are aware,...

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"