概述

  • 产品名称Anti-BMPR1A抗体
    参阅全部 BMPR1A 一抗
  • 描述
    山羊多克隆抗体to BMPR1A
  • 经测试应用适用于: WB, ELISAmore details
  • 种属反应性
    与反应: Human
    预测可用于: Dog
  • 免疫原

    Synthetic peptide:

    C-KSDSDQKKSEN

    , corresponding to internal sequence amino acids 36-46 of Human BMPR1A

  • 阳性对照
    • HeLa cell lysate.

性能

应用

Our Abpromise guarantee covers the use of ab52023 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB
ELISA
  • 应用说明Peptide ELISA: Antibody detection limit dilution 1:16,000.
    WB: Use at a concentration of 1.0 - 3.0 µg/ml. Detects a band of approximately 60 kDa in lysates of cell lines HeLa and HepG2(predicted molecular weight: 60 kDa).

    An additional band of 20kDa was consistently observed, however this band was not blocked by the immunizing peptide and it is therefore a non-specific signal. We call for caution when used for other assays than Western blot.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP2, BMP4, GDF5 and GDF6. Positively regulates chondrocyte differentiation through GDF5 interaction. Mediates induction of adipogenesis by GDF6.
    • 组织特异性Highly expressed in skeletal muscle.
    • 疾病相关Juvenile polyposis syndrome
      Polyposis syndrome, mixed hereditary 2
      A microdeletion of chromosome 10q23 involving BMPR1A and PTEN is a cause of chromosome 10q23 deletion syndrome, which shows overlapping features of the following three disorders: Bannayan-Zonana syndrome, Cowden disease and juvenile polyposis syndrome.
    • 序列相似性Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
      Contains 1 GS domain.
      Contains 1 protein kinase domain.
    • 细胞定位Membrane.
    • Information by UniProt
    • 数据库链接
    • 别名
      • 10q23del antibody
      • Activin A receptor type II like kinase 3 antibody
      • Activin receptor like kinase 3 antibody
      • Activin receptor-like kinase 3 antibody
      • ACVRLK 3 antibody
      • ACVRLK3 antibody
      • ALK 3 antibody
      • ALK-3 antibody
      • ALK3 antibody
      • BMP type-1A receptor antibody
      • BMPR 1A antibody
      • Bmpr antibody
      • BMPR-1A antibody
      • Bmpr1a antibody
      • BMR1A_HUMAN antibody
      • Bone morphogenetic protein receptor type IA antibody
      • Bone morphogenetic protein receptor type IA precursor antibody
      • Bone morphogenetic protein receptor type-1A antibody
      • BR 1a antibody
      • BR1a antibody
      • CD 292 antibody
      • CD292 antibody
      • CD292 antigen antibody
      • EC 2.7.11.30 antibody
      • Serine threonine protein kinase receptor R5 antibody
      • Serine threonine protein kinase receptor R5 precursor antibody
      • Serine/threonine-protein kinase receptor R5 antibody
      • SKR 5 antibody
      • SKR5 antibody
      • zBMPR IA antibody
      • zBMPRIA antibody
      see all

    Anti-BMPR1A antibody 图像

    Anti-BMPR1A antibody (ab52023)参考文献

    ab52023 has not yet been referenced specifically in any publications.

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