- 数据表
- 具体的参考文献 (1)
- 实验方案
概述
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产品名称Anti-BMP9抗体
参阅全部 BMP9 一抗 -
描述兔多克隆抗体to BMP9
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宿主Rabbit
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经测试应用适用于: WB, IHC-P, ELISAmore details
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种属反应性与反应: Mouse, Human
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免疫原
Synthetic peptide from the N-terminal region of human BMP9 conjugated to KLH
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阳性对照
- Mouse liver tissue lysate and human hepatocellular carcinoma tissue.
性能
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形式Liquid
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存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
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存储溶液Preservative: 0.09% Sodium Azide
Constituents: PBS -
Concentration information loading... -
纯度Protein G purified
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克隆多克隆
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同种型IgG
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研究领域
相关产品
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Compatible Secondaries
应用
Our Abpromise guarantee covers the use of ab71809 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| 应用 | Ab评论 | 说明 |
|---|---|---|
| WB | 1/100 - 1/500. Detects a band of approximately 50 kDa (predicted molecular weight: 47 kDa). | |
| IHC-P | 1/50 - 1/100. | |
| ELISA | 1/1000. |
靶标
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相关性BMP9 is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. They are regulators of cell growth and differentiation. BMP9 has a role in the maturation of BFCN (basal forebrain cholinergic neurons) also inducing and maintaining the ability of these cells to respond to acetylcholine; BFCN are important for the processes of learning, memory and attention. BMP9 is a potent inducer of hepcidin (a cationic peptide that has a antimicrobial properties) in hepatocytes and can regulate iron metabolism. The physiological receptor of BMP9 is thought to be activin receptor-like kinase 1, ALK1 (also called ACVRL1), an endothelial-specific type I receptor of the TGF-beta receptor family. BMP9 is one of the most potent BMPs to induce orthotopic bone formation in vivo. BMP3, a blocker of most BMPs seems not to affect BMP9.
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细胞定位Secreted
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数据库链接
- Entrez Gene: 2658 Human
- Entrez Gene: 12165 Mouse
- Omim: 605120 Human
- SwissProt: Q9UK05 Human
- SwissProt: Q9WV56 Mouse
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别名
- BMP 9 antibody
- Bone morphogenetic protein 9 antibody
- GDF 2 antibody
see all
图片
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Western blot - BMP9 antibody (ab71809)Anti-BMP9 antibody (ab71809) at 1/100 dilution + mouse liver tissue lysate at 12.5 µg
Predicted band size: 47 kDa
Observed band size: 50 kDa (why is the actual band size different from the predicted?) -
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - BMP9 antibody (ab71809)ab71809 at 1/50 dilution, staining BMP9 in human hepatocarcinoma by Immunohistochemistry, Formalin-fixed, Paraffin-embedded tissue, followed by peroxidase-conjugated secondary antibody and DAB staining.
文献
This product has been referenced in:
- Wang T et al. Inhibitory effects of BMP9 on breast cancer cells by regulating their interaction with pre-adipocytes/adipocytes. Oncotarget 8:35890-35901 (2017). Read more (PubMed: 28415788) »
客户评价及客户问答
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"