重组Anti-BMP15抗体[EPR5137] (ab108413)
Key features and details
- Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply
- Rabbit monoclonal [EPR5137] to BMP15
- Suitable for: WB, Flow Cyt (Intra)
- Reacts with: Human
Related conjugates and formulations
概述
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产品名称
Anti-BMP15抗体[EPR5137]
参阅全部 BMP15 一抗 -
描述
兔单克隆抗体[EPR5137] to BMP15 -
宿主
Rabbit -
经测试应用
适用于: WB, Flow Cyt (Intra)more details
不适用于: ICC/IF,IHC-P or IP -
种属反应性
与反应: Human
预测可用于: Mouse, Rat -
免疫原
Synthetic peptide. This information is proprietary to Abcam and/or its suppliers.
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阳性对照
- Ovary cancer, uterus, HL-60, NIH:OVCAR-3, Human testis, and HeLa cell lysates; Hela cells
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常规说明
This product is a recombinant monoclonal antibody, which offers several advantages including:
- - High batch-to-batch consistency and reproducibility
- - Improved sensitivity and specificity
- - Long-term security of supply
- - Animal-free production
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C. -
解离常数(KD)
KD = 8.80 x 10 -11 M Learn more about KD -
存储溶液
pH: 7.20
Preservative: 0.05% Sodium azide
Constituents: 0.1% BSA, 40% Glycerol (glycerin, glycerine), 9.85% Tris glycine, 50% Tissue culture supernatant -
Concentration information loading...
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纯度
Protein A purified -
克隆
单克隆 -
克隆编号
EPR5137 -
同种型
IgG -
研究领域
相关产品
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Alternative Versions
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Isotype control
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Recombinant Protein
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab108413于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
---|---|---|
WB |
1/1000 - 1/10000. Predicted molecular weight: 45 kDa.
|
|
Flow Cyt (Intra) |
1/10 - 1/100.
ab172730 - Rabbit monoclonal IgG, is suitable for use as an isotype control with this antibody. |
说明 |
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WB
1/1000 - 1/10000. Predicted molecular weight: 45 kDa. |
Flow Cyt (Intra)
1/10 - 1/100. ab172730 - Rabbit monoclonal IgG, is suitable for use as an isotype control with this antibody. |
靶标
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功能
May be involved in follicular development. Oocyte-specific growth/differentiation factor that stimulates folliculogenesis and granulosa cell (GC) growth. -
疾病相关
Defects in BMP15 are the cause of ovarian dysgenesis type 2 (ODG2) [MIM:300510]; also known as X-linked hypergonadotropic ovarian dysgenesis or hypergonadotropic ovarian failure due to ovarian dysgenesis. Ovarian dysgenesis leads to ovarian failure and accounts for about half of the cases of primary amenorrhea.
Defects in BMP15 are the cause of premature ovarian failure type 4 (POF4) [MIM:300510]. An ovarian disorder defined as the cessation of ovarian function under the age of 40 years. It is characterized by oligomenorrhea or amenorrhea, in the presence of elevated levels of serum gonadotropins and low estradiol. -
序列相似性
Belongs to the TGF-beta family. -
细胞定位
Secreted. - Information by UniProt
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数据库链接
- Entrez Gene: 9210 Human
- Entrez Gene: 12155 Mouse
- Entrez Gene: 59302 Rat
- Omim: 300247 Human
- SwissProt: O95972 Human
- SwissProt: Q9Z0L4 Mouse
- Unigene: 532692 Human
- Unigene: 42160 Mouse
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别名
- BMP 15 antibody
- BMP-15 antibody
- BMP15 antibody
see all
图片
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All lanes : Anti-BMP15 antibody [EPR5137] (ab108413) at 1/1000 dilution
Lane 1 : Ovary cancer tissue lysate
Lane 2 : Uterus tissue lysate
Lane 3 : HL-60 cell lysate
Lane 4 : NIH:OVCAR-3 cell lysate
Lane 5 : Human testis tissue lysate
Lane 6 : HeLa cell lysate
Lysates/proteins at 10 µg per lane.
Predicted band size: 45 kDa -
Intracellular flow cytometric analysis of BMP15 in permeabilized Hela cells using ab108413 at 1/10 dilution (red) or a rabbit IgG (negative) (green).
数据表及文件
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SDS download
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Datasheet download
文献 (2)
ab108413 被引用在 2 文献中.
- Li D et al. MicroRNA-375 represses tumor angiogenesis and reverses resistance to sorafenib in hepatocarcinoma. Cancer Gene Ther 28:126-140 (2021). PubMed: 32616906
- Pelosi E et al. Constitutively active Foxo3 in oocytes preserves ovarian reserve in mice. Nat Commun 4:1843 (2013). Mouse . PubMed: 23673628