概述

  • 产品名称Anti-BMP10抗体
    参阅全部 BMP10 一抗
  • 描述
    兔多克隆抗体to BMP10
  • 经测试应用适用于: IHC-P, ELISAmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat
  • 免疫原

    Synthetic peptide:

    SPIMNLEQSPLEED

    conjugated to KLH, corresponding to N terminal amino acids 22-35 of Human BMP10 (NP_055297.1).

  • 阳性对照
    • Human heart tissue.

性能

应用

Our Abpromise guarantee covers the use of ab118398 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P Use a concentration of 20 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
ELISA 1/1 - 1/1000.

靶标

  • 功能Required for maintaining the proliferative activity of embryonic cardiomyocytes by preventing premature activation of the negative cell cycle regulator CDKN1C/p57KIP and maintaining the required expression levels of cardiogenic factors such as MEF2C and NKX2-5. Acts as a ligand for ACVRL1/ALK1, BMPR1A/ALK3 and BMPR1B/ALK6, leading to activation of SMAD1, SMAD5 and SMAD8 transcription factors. Inhibits endothelial cell migration and growth.
  • 序列相似性Belongs to the TGF-beta family.
  • 细胞定位Secreted.
  • Information by UniProt
  • 数据库链接
  • 别名
    • BMP-10 antibody
    • Bmp10 antibody
    • BMP10_HUMAN antibody
    • Bone morphogenetic protein 10 antibody
    • Bone morphogenetic protein 10 preproprotein antibody
    • MGC126783 antibody
    • OTTHUMP00000159973 antibody
    see all

Anti-BMP10 antibody 图像

  • ab118398, at 20 µg/ml, staining BMP10 in Formalin-fixed, Paraffin-embedded Human heart tissue by Immunohistochemistry followed by biotinylated secondary antibody, alkaline phosphatase-streptavidin and chromogen.

Anti-BMP10 antibody (ab118398)参考文献

ab118398 has not yet been referenced specifically in any publications.

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