概述

  • 产品名称Anti-Bmi1抗体
    参阅全部 Bmi1 一抗
  • 描述
    兔多克隆抗体to Bmi1
  • 经测试应用适用于: IHC-Pmore details
    不适用于: WB
  • 种属反应性
    与反应: Human
  • 免疫原

    KLH conjugated synthetic peptide selected from the central region of Human BMI (NP_005171).

性能

应用

Our Abpromise guarantee covers the use of ab97729 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P 1/50 - 1/100. Perform heat mediated antigen retrieval in Sodium citrate pH6 buffer before commencing with IHC staining protocol.
  • 应用说明Is unsuitable for WB.
  • 靶标

    • 功能Component of the Polycomb group (PcG) multiprotein PRC1 complex, a complex required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. In the PRC1 complex, it is required to stimulate the E3 ubiquitin-protein ligase activity of RNF2/RING2.
    • 序列相似性Contains 1 RING-type zinc finger.
    • 翻译后修饰Monoubiquitinated (By similarity). May be polyubiquitinated; which does not lead to proteasomal degradation.
    • 细胞定位Nucleus. Cytoplasm.
    • Information by UniProt
    • 数据库链接
    • 别名
      • B lymphoma Mo MLV insertion region (mouse) antibody
      • B lymphoma Mo MLV insertion region 1 homolog antibody
      • Bmi 1 antibody
      • BMI1 antibody
      • BMI1 polycomb ring finger oncogene antibody
      • BMI1_HUMAN antibody
      • Flvi 2/bmi 1 antibody
      • FLVI2/BMI1 antibody
      • MGC12685 antibody
      • Murine leukemia viral (bmi 1) oncogene homolog antibody
      • Oncogene BMI 1 antibody
      • PCGF 4 antibody
      • PCGF4 antibody
      • Polycomb complex protein BMI 1 antibody
      • Polycomb complex protein BMI-1 antibody
      • Polycomb group protein Bmi1 antibody
      • Polycomb group ring finger 4 antibody
      • Polycomb group RING finger protein 4 antibody
      • RING finger protein 51 antibody
      • RNF 51 antibody
      • RNF51 antibody
      see all

    Anti-Bmi1 antibody 图像

    • (A) IHC staining for Bmi1 expression in primary Human neuroblastoma sample. A significant number of tumor cells show strong nuclear staining of Bmi1 (brown). (B) Immunohistochemical staining of SCG and neuroblastoma samples for Bmi1.

    Anti-Bmi1 antibody (ab97729)参考文献

    ab97729 has not yet been referenced specifically in any publications.

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