概述

  • 产品名称Anti-Blood Group Wrb抗体[E6]
  • 描述
    小鼠单克隆抗体[E6] to Blood Group Wrb
  • 特异性ab50293 binds to Wrb, a composite blood group antigen resulting from the association between Glycophorin A and Band 3. The antibody (also cited as clone no. 7H12) binds to 9% of bone marrow nucleated cells in smears and tissue preparations using immunofluorescent microscopy or flow cytometry.
  • 经测试应用适用于: Flow Cyt, Agglutination, ICC/IFmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Human thymus

  • 阳性对照
    • Human erythrocytes (agglutination) and bone marrow nucleated cells (flow cytometry and indirect immunofluorescence)

性能

应用

Our Abpromise guarantee covers the use of ab50293 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
Flow Cyt Use at an assay dependent concentration. ab170192-Mouse monoclonal IgG2b, is suitable for use as an isotype control with this antibody.
Agglutination 1/10.
ICC/IF Use at an assay dependent concentration.

靶标

  • 相关性Wrb is a composite blood group antigen resulting from the association between Glycophorin A and Band 3. Wrb directly agglutinates erythrocytes, giving reduced deformability and inhibition of malarial parasite invasion (eg P. falciparum, P. knowles). The antigen is thought to be related to Glycophorin A/Band 3 interaction in the lipid bilayer.
  • 细胞定位Cell Membrane and Nuclear
  • 数据库链接
  • 别名
    • CHD5 antibody
    • Congenital heart disease 5 protein antibody
    • Tryptophan rich basic protein antibody
    • WRB antibody

Anti-Blood Group Wrb antibody [E6] (ab50293)参考文献

This product has been referenced in:
  • Telen MJ & Bolk TA Human red cell antigens. IV. The abnormal sialoglycoprotein of Gerbich-negative red cells. Transfusion 27:309-14 (1987). Read more (PubMed: 3603658) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"