Anti-Blood Group H2 antigen抗体[BRIC231] (ab33404)

概述

  • 产品名称Anti-Blood Group H2 antigen抗体[BRIC231]
  • 描述
    小鼠单克隆抗体[BRIC231] to Blood Group H2 antigen
  • 经测试应用适用于: Agglutination, Flow Cytmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Tissue/ cell preparation (Human) -HEL cell line.

性能

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Our Abpromise guarantee covers the use of ab33404 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
Agglutination Use at an assay dependent concentration.
Flow Cyt Use 10µl for 106 cells. ab170190-Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody.

靶标

  • 功能This protein is the basis of the ABO blood group system. The histo-blood group ABO involves three carbohydrate antigens: A, B, and H. A, B, and AB individuals express a glycosyltransferase activity that converts the H antigen to the A antigen (by addition of UDP-GalNAc) or to the B antigen (by addition of UDP-Gal), whereas O individuals lack such activity.
  • 通路Protein modification; protein glycosylation.
  • 序列相似性Belongs to the glycosyltransferase 6 family.
  • 结构域The conserved DXD motif is involved in cofactor binding. The manganese ion interacts with the beta-phosphate group of UDP and may also have a role in catalysis.
  • 翻译后修饰The soluble form derives from the membrane form by proteolytic processing.
  • 细胞定位Golgi apparatus > Golgi stack membrane. Secreted. Membrane-bound form in trans cisternae of Golgi. Secreted into the body fluid.
  • Information by UniProt
  • 数据库链接
  • 别名
    • A transferase antibody
    • Abo antibody
    • B transferase antibody
    • BGAT_HUMAN antibody
    • CD173 antibody
    • Fucosylglycoprotein 3-alpha-galactosyltransferase antibody
    • Fucosylglycoprotein alpha-N-acetylgalactosaminyltransferase antibody
    • Fucosylglycoprotein alpha-N-acetylgalactosaminyltransferase soluble form antibody
    • Glycoprotein-fucosylgalactoside alpha-galactosyltransferase antibody
    • Glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase antibody
    • Histo-blood group A transferase antibody
    • Histo-blood group B transferase antibody
    • NAGAT antibody
    see all

Anti-Blood Group H2 antigen antibody [BRIC231] (ab33404)参考文献

This product has been referenced in:
  • Gao C  et al. Carbohydrate Sequence of the Prostate Cancer-associated Antigen F77 Assigned by a Mucin O-Glycome Designer Array. J Biol Chem 289:16462-77 (2014). Read more (PubMed: 24753245) »

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