概述

  • 产品名称
  • 描述
    兔多克隆抗体to BLK
  • 特异性
    This antibody detects 27 kD mouse BLK in tissue extracts.
  • 经测试应用
    适用于: WBmore details
  • 种属反应性
    与反应: Mouse
  • 免疫原

    Synthetic peptide conjugated to KLH, corresponding to amino acids 25-42 of Mouse BLK.

性能

  • 形式
    Liquid
  • 存放说明
    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • 存储溶液
    Preservative: 0.02% Thimerosal (merthiolate)
    Constituents: 50% Glycerol, 1% BSA, PBS, pH 7.2
  • Concentration information loading...
  • 纯度
    Immunogen affinity purified
  • 克隆
    多克隆
  • 同种型
    IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab2390 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml.

靶标

  • 功能
    Modulator of beta-cells function, acting through the up-regulation of PDX1 and NKX6-1 and consequent stimulation of insulin secretion in response to glucose.
  • 组织特异性
    Expressed in lymphatic organs, pancreatic islets, Leydig cells, striate ducts of salivary glands and hair follicles.
  • 疾病相关
    Defects in BLK are a cause of maturity-onset diabetes of the young type 11 (MODY11) [MIM:613375]. MODY11 is a form of diabetes that is characterized by an autosomal dominant mode of inheritance, onset in childhood or early adulthood (usually before 25 years of age), a primary defect in insulin secretion and frequent insulin-independence at the beginning of the disease.
  • 序列相似性
    Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.
    Contains 1 protein kinase domain.
    Contains 1 SH2 domain.
    Contains 1 SH3 domain.
  • Information by UniProt
  • 数据库链接
  • 别名
    • B lymphocyte kinase antibody
    • B lymphoid tyrosine kinase antibody
    • Blk antibody
    • BLK nonreceptor tyrosine kinase antibody
    • BLK_HUMAN antibody
    • EC 2.7.10.2 antibody
    • MGC 10442 antibody
    • MGC10442 antibody
    • MODY 11 antibody
    • MODY11 antibody
    • P55 BLK antibody
    • p55-BLK antibody
    • Tyrosine kinase B lymphocyte specific antibody
    • Tyrosine protein kinase antibody
    • Tyrosine-protein kinase BLK antibody
    see all

实验方案

文献

ab2390 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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