概述

  • 产品名称Bisdemethoxycurcumin
  • 描述
    Apoptotic anticancer, anti-inflammatory and antioxidant curcuminoid
  • 别名
    • BDMC
    • Bisdesmethoxycurcumin
    • Curcumin III
    • Didemethoxycurcumin
  • 生物学描述Apoptotic anticancer, anti-inflammatory and antioxidant curcuminoid. Inhibits wnt activity through activation of WIF-1. Induces demethylation through DNA methyltransferase 1 inhibition. Potent and competitive aldo-keto reductase inhibitor (Ki = 22 nM).
  • 纯度> 98%

性能

    应用

    Our Abpromise guarantee covers the use of ab120976 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    应用 Ab评论 说明
    Functional Studies Use at an assay dependent concentration.

    Bisdemethoxycurcumin 图像

    • ab18210 staining Bcl2 in HeLa cells treated with bisdemethoxycurcumin (ab120976), by ICC/IF. Decrease of Bcl2 expression correlates with increased concentration of bisdemethoxycurcumin, as described in literature.
      The cells were incubated at 37°C for 6 hours in media containing different concentrations of ab120976 (bisdemethoxycurcumin) in DMSO, fixed with 100% methanol for 5 minutes at -20°C and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab18209 (5 µg/ml) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight 488 anti-rabbit polyclonal antibody (ab96899) at 1/250 dilution was used as the secondary antibody. Nuclei were counterstained with DAPI and are shown in blue.

    Bisdemethoxycurcumin (ab120976)参考文献

    This product has been referenced in:
    • Liu YL  et al. The hypomethylation agent bisdemethoxycurcumin acts on the WIF-1 promoter, inhibits the canonical Wnt pathway and induces apoptosis in human non-small-cell lung cancer. Curr Cancer Drug Targets 11:1098-110 (2011). Read more (PubMed: 21933103) »
    • Kim AN  et al. Up-regulation of heme oxygenase-1 expression through CaMKII-ERK1/2-Nrf2 signaling mediates the anti-inflammatory effect of bisdemethoxycurcumin in LPS-stimulated macrophages. Free Radic Biol Med 49:323-31 (2010). Read more (PubMed: 20430097) »
    • Matsunaga T  et al. Potent and selective inhibition of the tumor marker AKR1B10 by bisdemethoxycurcumin: probing the active site of the enzyme with molecular modeling and site-directed mutagenesis. Biochem Biophys Res Commun 389:128-32 (2009). Read more (PubMed: 19706287) »

    See 0 Publications for this product

    Product Wall

    There are currently no Abreviews or Questions for ab120976.
    Please use the links above to contact us or submit feedback about this product.

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"