概述

  • 产品名称Anti-BIN1抗体
    参阅全部 BIN1 一抗
  • 描述
    兔多克隆抗体to BIN1
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Mouse, Rat, Human
  • 免疫原

    Synthetic peptide (Mouse) - corresponding to region surrounding amino acid 578 of mouse BIN 1.

  • 阳性对照
    • Jurkat cells

性能

相关产品

应用

Our Abpromise guarantee covers the use of ab27796 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB
  • 应用说明WB: Use at a concentration of 0.5 - 2.0 µg/ml. Predicted molecular weight: 65 kDa and a 45kDa fragment can be detected in apoptotic samples.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能May be involved in regulation of synaptic vesicle endocytosis. May act as a tumor suppressor and inhibits malignant cell transformation.
    • 组织特异性Ubiquitous. Highest expression in the brain and muscle. Isoform IIA is expressed only in the brain where it is concentrated in axon initial segments and nodes of Ranvier. Isoform BIN1 is widely expressed with highest expression in skeletal muscle.
    • 疾病相关Defects in BIN1 are the cause of centronuclear myopathy autosomal recessive (ARCNM) [MIM:255200]; also known as autosomal recessive myotubular myopathy. Centronuclear myopathies are congenital muscle disorders characterized by progressive muscular weakness and wasting involving mainly limb girdle, trunk, and neck muscles. It may also affect distal muscles. Weakness may be present during childhood or adolescence or may not become evident until the third decade of life. Ptosis is a frequent clinical feature. The most prominent histopathologic features include high frequency of centrally located nuclei in muscle fibers not secondary to regeneration, radial arrangement of sarcoplasmic strands around the central nuclei, and predominance and hypotrophy of type 1 fibers.
    • 序列相似性Contains 1 BAR domain.
      Contains 1 SH3 domain.
    • 翻译后修饰Phosphorylated by protein kinase C.
    • 细胞定位Cytoplasm and Nucleus.
    • Information by UniProt
    • 数据库链接
    • 别名
      • AMPH 2 antibody
      • AMPH2 antibody
      • Amphiphysin 2 antibody
      • Amphiphysin II antibody
      • Amphiphysin like protein antibody
      • amphiphysin-like antibody
      • Amphiphysin-like protein antibody
      • AMPHL antibody
      • Bin1 antibody
      • BIN1_HUMAN antibody
      • Box Dependant MYC Interacting Protein 1 antibody
      • Box-dependent myc-interacting protein 1 antibody
      • Bridging integrator 1 antibody
      • DKFZp547F068 antibody
      • MGC10367 antibody
      • MGC105358 antibody
      • Myc box dependent interacting protein 1 antibody
      • Myc box-dependent-interacting protein 1 antibody
      • SH3P9 antibody
      see all

    Anti-BIN1 antibody 图像

    • All lanes : Anti-BIN1 antibody (ab27796) at 2 µg/ml

      Lane 1 : Jurkat whole cell lysate (ab7899)
      Lane 2 : Jurkat cells treated with camptothecin for 6 hours


      Predicted band size : 65 kDa
      Observed band size : 64 kDa (why is the actual band size different from the predicted?)
      Additional bands at : 48 kDa (possible cleavage fragment).

    Anti-BIN1 antibody (ab27796)参考文献

    This product has been referenced in:
    • Chapuis J  et al. Increased expression of BIN1 mediates Alzheimer genetic risk by modulating tau pathology. Mol Psychiatry N/A:N/A (2013). WB ; Human . Read more (PubMed: 23399914) »

    See 1 Publication for this product

    Product Wall

    I am sorry this product did not perform as stated on the datasheet and for the inconvenience this has caused. As requested, I have issued a free of charge replacement for one vial of ab27796 with the order number 1080280.

    To check the status...

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"