概述

  • 产品名称Anti-BIN1抗体
    参阅全部 BIN1 一抗
  • 描述
    山羊多克隆抗体to BIN1
  • 特异性ab106937 is expected to recognize isoform 1, 2, 3, 4, 5, 6, 7, 8, 9 and 10 (NP_647593.1, NP_647594.1, NP_647595.1, NP_647596.1, NP_647597.1, NP_647598.1, NP_647599.1, NP_004296.1, NP_647600.1, NP_647601.1).
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Cow, Pig
  • 免疫原

    Synthetic peptide:

    C-SDNAPAKGNKSPS

    , corresponding to internal sequence amino acids 286-298 of Human BIN1 (NP_647593.1)

  • 阳性对照
    • Human skeletal muscle lysates

性能

应用

Our Abpromise guarantee covers the use of ab106937 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 - 3 µg/ml. Detects a band of approximately 70, 60 kDa (predicted molecular weight: 65 kDa).

靶标

  • 功能May be involved in regulation of synaptic vesicle endocytosis. May act as a tumor suppressor and inhibits malignant cell transformation.
  • 组织特异性Ubiquitous. Highest expression in the brain and muscle. Isoform IIA is expressed only in the brain where it is concentrated in axon initial segments and nodes of Ranvier. Isoform BIN1 is widely expressed with highest expression in skeletal muscle.
  • 疾病相关Defects in BIN1 are the cause of centronuclear myopathy autosomal recessive (ARCNM) [MIM:255200]; also known as autosomal recessive myotubular myopathy. Centronuclear myopathies are congenital muscle disorders characterized by progressive muscular weakness and wasting involving mainly limb girdle, trunk, and neck muscles. It may also affect distal muscles. Weakness may be present during childhood or adolescence or may not become evident until the third decade of life. Ptosis is a frequent clinical feature. The most prominent histopathologic features include high frequency of centrally located nuclei in muscle fibers not secondary to regeneration, radial arrangement of sarcoplasmic strands around the central nuclei, and predominance and hypotrophy of type 1 fibers.
  • 序列相似性Contains 1 BAR domain.
    Contains 1 SH3 domain.
  • 翻译后修饰Phosphorylated by protein kinase C.
  • 细胞定位Cytoplasm and Nucleus.
  • Information by UniProt
  • 数据库链接
  • 别名
    • AMPH 2 antibody
    • AMPH2 antibody
    • Amphiphysin 2 antibody
    • Amphiphysin II antibody
    • Amphiphysin like protein antibody
    • amphiphysin-like antibody
    • Amphiphysin-like protein antibody
    • AMPHL antibody
    • Bin1 antibody
    • BIN1_HUMAN antibody
    • Box Dependant MYC Interacting Protein 1 antibody
    • Box-dependent myc-interacting protein 1 antibody
    • Bridging integrator 1 antibody
    • DKFZp547F068 antibody
    • MGC10367 antibody
    • MGC105358 antibody
    • Myc box dependent interacting protein 1 antibody
    • Myc box-dependent-interacting protein 1 antibody
    • SH3P9 antibody
    see all

Anti-BIN1 antibody 图像

  • Anti-BIN1 antibody (ab106937) at 0.1 µg/ml + Human skeletal muscle lysate (in RIPA buffer) at 35 µg
    Developed using the ECL technique

    Predicted band size : 65 kDa
    Observed band size : 60 + 70 kDa (why is the actual band size different from the predicted?)


    Exposure time : 1 hour

Anti-BIN1 antibody (ab106937)参考文献

ab106937 has not yet been referenced specifically in any publications.

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