Anti-Bim (phospho S59)抗体(ab112106)

概述

  • 产品名称Anti-Bim (phospho S59)抗体
    参阅全部 Bim 一抗
  • 描述
    兔多克隆抗体to Bim (phospho S59)
  • 特异性ab112106 detects endogenous levels of Bim only when phosphorylated at serine 59.
  • 经测试应用适用于: IHC-Pmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat
  • 免疫原

    Synthetic phosphopeptide derived from Human Bim around the phosphorylation site of serine 59 (H-G-SP-P-Q)

  • 阳性对照
    • Human brain tissue.

性能

应用

Our Abpromise guarantee covers the use of ab112106 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P 1/50 - 1/100. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

靶标

  • 功能Induces apoptosis. Isoform BimL is more potent than isoform BimEL. Isoform Bim-alpha1, isoform Bim-alpha2 and isoform Bim-alpha3 induce apoptosis, although less potent than the isoforms BimEL, BimL and BimS. Isoform Bim-gamma induces apoptosis.
  • 组织特异性Isoform BimEL, isoform BimL and isoform BimS are the predominant isoforms and are ubiquitously expressed with a tissue-specific variation. Isoform Bim-gamma is most abundantly expressed in small intestine and colon, and in lower levels in spleen, prostate, testis, heart, liver and kidney.
  • 序列相似性Belongs to the Bcl-2 family.
  • 结构域The BH3 motif is required for Bcl-2 binding and cytotoxicity.
  • 细胞定位Mitochondrion and Endomembrane system. Associated with intracytoplasmic membranes.
  • Information by UniProt
  • 数据库链接
  • 别名
    • BCL2 like 11 antibody
    • B2L11_HUMAN antibody
    • BAM antibody
    • Bcl 2 interacting protein Bim antibody
    • Bcl 2 related ovarian death agonist antibody
    • Bcl-2-like protein 11 antibody
    • BCL2 interacting mediator of cell death antibody
    • BCL2 like 11 (apoptosis facilitator) antibody
    • BCL2 like protein 11 antibody
    • Bcl2-interacting mediator of cell death antibody
    • Bcl2-L-11 antibody
    • Bcl2l11 antibody
    • BIM alpha6 antibody
    • BIM antibody
    • BIM beta6 antibody
    • BIM beta7 antibody
    • BimEL antibody
    • BimL antibody
    • BOD antibody
    see all

Anti-Bim (phospho S59) antibody 图像

  • ab112106, at a 1/50 dilution, staining Bim in Paraffin-embedded Human brain tissue by Immunohistochemistry, in the absence (left) and presence (right) of the phosphopeptide.

Anti-Bim (phospho S59) antibody (ab112106)参考文献

ab112106 has not yet been referenced specifically in any publications.

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