Anti-Bim抗体[Ham151-149] (ab93166)

概述

  • 产品名称
    Anti-Bim抗体[Ham151-149]
    参阅全部 Bim 一抗
  • 描述
    亚美尼亚仓鼠单克隆抗体[Ham151-149] to Bim
  • 经测试应用
    适用于: WB, IP, ICC, Flow Cytmore details
  • 种属反应性
    与反应: Mouse
  • 免疫原

    Mouse BimL (w/o transmembrane region) + Bcl-xL (w/o transmembrane region)-6-his tag, purified from Hi5 cells

性能

应用

Our Abpromise guarantee covers the use of ab93166 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB
IP
ICC
Flow Cyt
  • 应用说明
    Flow Cyt: Use at a concentration of 10 µg/ml. Use cells permeabilized with 0.03% saponin
    ICC: Use at an assay dependent dilution. Use permeabilized cells
    IP: Use 1 - 2µg/100-500 µg protein in 1 ml lysate.
    WB: Use at a concentration of 1 - 2 µg/ml (reduced conditions). Predicted molecular weight: 22 kDa.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能
      Induces apoptosis. Isoform BimL is more potent than isoform BimEL. Isoform Bim-alpha1, isoform Bim-alpha2 and isoform Bim-alpha3 induce apoptosis, although less potent than the isoforms BimEL, BimL and BimS. Isoform Bim-gamma induces apoptosis.
    • 组织特异性
      Isoform BimEL, isoform BimL and isoform BimS are the predominant isoforms and are ubiquitously expressed with a tissue-specific variation. Isoform Bim-gamma is most abundantly expressed in small intestine and colon, and in lower levels in spleen, prostate, testis, heart, liver and kidney.
    • 序列相似性
      Belongs to the Bcl-2 family.
    • 结构域
      The BH3 motif is required for Bcl-2 binding and cytotoxicity.
    • 细胞定位
      Mitochondrion and Endomembrane system. Associated with intracytoplasmic membranes.
    • Information by UniProt
    • 数据库链接
    • 别名
      • BCL2 like 11 antibody
      • B2L11_HUMAN antibody
      • BAM antibody
      • Bcl 2 interacting protein Bim antibody
      • Bcl 2 related ovarian death agonist antibody
      • Bcl-2-like protein 11 antibody
      • BCL2 interacting mediator of cell death antibody
      • BCL2 like 11 (apoptosis facilitator) antibody
      • BCL2 like protein 11 antibody
      • Bcl2-interacting mediator of cell death antibody
      • Bcl2-L-11 antibody
      • Bcl2l11 antibody
      • BIM alpha6 antibody
      • BIM antibody
      • BIM beta6 antibody
      • BIM beta7 antibody
      • BimEL antibody
      • BimL antibody
      • BOD antibody
      see all

    Anti-Bim antibody [Ham151-149] (ab93166)参考文献

    ab93166 has not yet been referenced specifically in any publications.

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