概述

  • 产品名称Anti-Bim抗体
    参阅全部 Bim 一抗
  • 描述
    山羊多克隆抗体to Bim
  • 特异性This antibody is expected to recognise 3 reported isoforms: BimAD, BimACD, and BimABCD
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide:

    FNAYYARRLEK

    , corresponding to amino acids 159-169 of Human Bim.

性能

应用

Our Abpromise guarantee covers the use of ab17031 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 0.5 - 2 µg/ml. Detects a band of approximately 23 kDa (predicted molecular weight: 19, 9, 12 kDa).

靶标

  • 功能Induces apoptosis. Isoform BimL is more potent than isoform BimEL. Isoform Bim-alpha1, isoform Bim-alpha2 and isoform Bim-alpha3 induce apoptosis, although less potent than the isoforms BimEL, BimL and BimS. Isoform Bim-gamma induces apoptosis.
  • 组织特异性Isoform BimEL, isoform BimL and isoform BimS are the predominant isoforms and are ubiquitously expressed with a tissue-specific variation. Isoform Bim-gamma is most abundantly expressed in small intestine and colon, and in lower levels in spleen, prostate, testis, heart, liver and kidney.
  • 序列相似性Belongs to the Bcl-2 family.
  • 结构域The BH3 motif is required for Bcl-2 binding and cytotoxicity.
  • 细胞定位Mitochondrion and Endomembrane system. Associated with intracytoplasmic membranes.
  • Information by UniProt
  • 数据库链接
  • 别名
    • BCL2 like 11 antibody
    • B2L11_HUMAN antibody
    • BAM antibody
    • Bcl 2 interacting protein Bim antibody
    • Bcl 2 related ovarian death agonist antibody
    • Bcl-2-like protein 11 antibody
    • BCL2 interacting mediator of cell death antibody
    • BCL2 like 11 (apoptosis facilitator) antibody
    • BCL2 like protein 11 antibody
    • Bcl2-interacting mediator of cell death antibody
    • Bcl2-L-11 antibody
    • Bcl2l11 antibody
    • BIM alpha6 antibody
    • BIM antibody
    • BIM beta6 antibody
    • BIM beta7 antibody
    • BimEL antibody
    • BimL antibody
    • BOD antibody
    see all

Anti-Bim antibody 图像

  • Anti-Bim antibody (ab17031) at 0.5 µg/ml + Cell lysates prepared from Human K562 cells at 35 µg

    Predicted band size : 19, 9, 12 kDa

Anti-Bim antibody (ab17031)参考文献

This product has been referenced in:
  • Holmberg C  et al. Release of TGFßig-h3 by gastric myofibroblasts slows tumor growth and is decreased with cancer progression. Carcinogenesis 33:1553-62 (2012). Human . Read more (PubMed: 22610072) »

See 1 Publication for this product

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