概述

  • 产品名称Anti-Bile Acid Receptor NR1H4抗体
    参阅全部 Bile Acid Receptor NR1H4 一抗
  • 描述
    小鼠单克隆抗体to Bile Acid Receptor NR1H4
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Recombinant fragment, corresponding to amino acids 363-473 of Human Bile Acid Receptor NR1H4

性能

应用

Our Abpromise guarantee covers the use of ab56902 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB
  • 应用说明WB: Use at a concentration of 1-5 µg/ml.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Ligand-activated transcription factor. Receptor for bile acids such as chenodeoxycholic acid, lithocholic acid and deoxycholic acid. Represses the transcription of the cholesterol 7-alpha-hydroxylase gene (CYP7A1) through the induction of NR0B2 or FGF19 expression, via two distinct mechanisms. Activates the intestinal bile acid-binding protein (IBABP). Activates the transcription of bile salt export pump ABCB11 by directly recruiting histone methyltransferase CARM1 to this locus.
    • 序列相似性Belongs to the nuclear hormone receptor family. NR1 subfamily.
      Contains 1 nuclear receptor DNA-binding domain.
    • 细胞定位Nucleus.
    • Information by UniProt
    • 数据库链接
    • 别名
      • BAR antibody
      • Bile acid receptor antibody
      • Farnesoid X activated receptor antibody
      • Farnesoid X receptor antibody
      • Farnesoid X-activated receptor antibody
      • Farnesol receptor HRR 1 antibody
      • Farnesol receptor HRR-1 antibody
      • Farnesol receptor HRR1 antibody
      • FXR antibody
      • HRR 1 antibody
      • HRR1 antibody
      • NR1H4 antibody
      • NR1H4_HUMAN antibody
      • Nuclear receptor subfamily 1 group H member 4 antibody
      • Retinoid X receptor interacting protein 14 antibody
      • Retinoid X receptor-interacting protein 14 antibody
      • RIP 14 antibody
      • RIP14 antibody
      • RXR interacting protein 14 antibody
      • RXR-interacting protein 14 antibody
      see all

    Anti-Bile Acid Receptor NR1H4 antibody 图像



    • Predicted band size : 56 kDa
      Bile Acid Receptor NR1H4 antibody (ab56902) at 1ug/lane + HepG2 cell lysate at 25ug/lane.

    Anti-Bile Acid Receptor NR1H4 antibody (ab56902)参考文献

    This product has been referenced in:
    • Vaquero J  et al. Differential activation of the human farnesoid X receptor depends on the pattern of expressed isoforms and the bile acid pool composition. Biochem Pharmacol 86:926-39 (2013). WB . Read more (PubMed: 23928191) »

    See 1 Publication for this product

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"