RabMAb

Anti-Bid Cleavage Site抗体[EPR9] (ab108293)

概述

  • 产品名称Anti-Bid Cleavage Site抗体[EPR9]
    参阅全部 Bid Cleavage Site 一抗
  • 描述
    兔单克隆抗体[EPR9] to Bid Cleavage Site
  • 经测试应用适用于: WBmore details
    不适用于: Flow Cyt,ICC,IHC-P or IP
  • 种属反应性
    与反应: Human
  • 免疫原

    A synthetic peptide corresponding to residues in Human Bid Cleavage Site

  • 阳性对照
    • Jurkat, 293T and Human fetal brain lysates
  • 常规说明

    This product is a recombinant rabbit monoclonal antibody.

    Produced using Abcam’s RabMAb® technology. RabMAb® technology is covered by the following U.S. Patents, No. 5,675,063 and/or 7,429,487.

    Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species. Please contact us for more information.

性能

应用

Our Abpromise guarantee covers the use of ab108293 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/1000 - 1/10000. Predicted molecular weight: 22 kDa.
  • 应用说明Is unsuitable for Flow Cyt,ICC,IHC-P or IP.
  • 靶标

    • 相关性Bid, a BH3 domain containing proapoptotic Bcl2 family member, is localized in the cytosolic fraction of cells as an inactive precursor. Its active form is generated upon proteolytic cleavage by caspase 8 in the Fas signaling pathway. Cleaved Bid translocates to mitochondria and releases its potent proapoptotic activity, which in turn induces cytochrome c release and mitochondrial damage. The cytochrome c releasing activity of Bid was antagonized by Bcl2. Mutation in the SH3 domain can diminish the cytochrome c releasing activity. In animal model studies, Bid deficient mice are found resistant to the lethal effects of death factor signals relayed through Fas.
    • 数据库链接
    • 别名
      • Apoptic death agonist antibody
      • BH 3 interacting domain death agonist antibody
      • BH3 interacting domain death agonist antibody
      • BID antibody
      • BID isoform ES(1b) antibody
      • BID isoform L(2) antibody
      • BID isoform Si6 antibody
      • Desmocollin type 4 antibody
      • FP497 antibody
      • Human BID coding sequence antibody
      • MGC15319 antibody
      • MGC42355 antibody
      • p22 BID antibody
      see all

    Anti-Bid Cleavage Site antibody [EPR9] 图像

    • All lanes : Anti-Bid Cleavage Site antibody [EPR9] (ab108293) at 1/1000 dilution

      Lane 1 : Jurkat lysate
      Lane 2 : 293T lysate
      Lane 3 : Human fetal brain lysate

      Lysates/proteins at 10 µg per lane.


      Predicted band size : 22 kDa

    Anti-Bid Cleavage Site antibody [EPR9] (ab108293)参考文献

    ab108293 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"