Anti-BHLHA15抗体[6E8/A12/C11P1] (ab110919)

概述

  • 产品名称
    Anti-BHLHA15抗体[6E8/A12/C11P1]
    参阅全部 BHLHA15 一抗
  • 描述
    小鼠单克隆抗体[6E8/A12/C11P1] to BHLHA15
  • 经测试应用
    适用于: WB, IHC-P, IHC-Frmore details
  • 种属反应性
    与反应: Mouse, Human
  • 免疫原

    Synthetic peptide, corresponding to C terminal amino acids 175-197 of Mouse BHLHA15.

  • 阳性对照
    • Mouse pancreas tissue.

性能

应用

Our Abpromise guarantee covers the use of ab110919 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/250. Predicted molecular weight: 21 kDa.
IHC-P 1/50.
IHC-Fr Use at an assay dependent dilution.

靶标

  • 功能
    Plays a role in controlling the transcriptional activity of MYOD1, ensuring that expanding myoblast populations remain undifferentiated. Repression may occur through muscle-specific E-box occupancy by homodimers. May also negatively regulate bHLH-mediated transcription through an N-terminal repressor domain. Serves as a key regulator of acinar cell function, stability, and identity. Also required for normal organelle localization in exocrine cells and for mitochondrial calcium ion transport. May function as a unique regulator of gene expression in several different embryonic and postnatal cell lineages. Binds to the E-box consensus sequence 5'-CANNTG-3'.
  • 组织特异性
    Expressed in brain, liver, spleen and skeletal muscle.
  • 序列相似性
    Contains 1 basic helix-loop-helix (bHLH) domain.
  • 结构域
    Lacks a classic transcription activation domain and instead possesses an N-terminal region capable of inhibiting heterologous activators.
  • 细胞定位
    Nucleus.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Basic helix loop helix domain containing class B 8 antibody
    • Basic helix loop helix family member a15 antibody
    • BHA15_HUMAN antibody
    • Bhlha15 antibody
    • bHLHB8 antibody
    • Class A basic helix-loop-helix protein 15 antibody
    • Class B basic helix-loop-helix protein 8 antibody
    • Class II bHLH protein MIST1 antibody
    • intestine and stomach expression 1 antibody
    • MIST 1 antibody
    • MIST-1 antibody
    • MIST1 antibody
    • Muscle antibody
    • Muscle intestine and stomach expression 1 antibody
    • protein MIST1 antibody
    see all

图片

  • ab110919 staining BHLHA15 in paraffin-embedded Mouse pancreas tissue by Immunohistochemistry. Note: nuclear staining in acinar cells but not in duct or islet cells.

文献

ab110919 has not yet been referenced specifically in any publications.

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