概述

  • 产品名称Anti-BFSP2抗体
    参阅全部 BFSP2 一抗
  • 描述
    兔多克隆抗体to BFSP2
  • 经测试应用适用于: IHC-P, ICC/IFmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    antigen sequence: LSRNYEEDVK LLHKQLAGCE LEQMDAPIGT GLDDILETIR IQWERDVEKN RVEAGALLQA KQQAEVAHMS QTQEEKLAAA LRVE, corresponding to internal sequence amino acids 237-320 of Human BFSP2.

  • 阳性对照
    • Human lateral ventricle tissue; A 431 cells.

性能

应用

Our Abpromise guarantee covers the use of ab122476 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P 1/2500 - 1/5000. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
ICC/IF Use a concentration of 1 - 4 µg/ml. using PFA/Triton X-100 Fixation/Permeabilization.

靶标

  • 功能Involved in stabilization of lens fiber cell cytoskeleton.
  • 组织特异性Lens.
  • 疾病相关Defects in BFSP2 are the cause of cataract autosomal dominant BFSP2-related (ADC-BFSP2) [MIM:611597]; also known as cataract autosomal dominant multiple types 1. Cataract is an opacification of the crystalline lens of the eye that frequently results in visual impairment or blindness. Opacities vary in morphology, are often confined to a portion of the lens, and may be static or progressive. In general, the more posteriorly located and dense an opacity, the greater the impact on visual function. Cataract autosomal dominant BFSP2-related is characterized by a variable phenotype that may or may not be consistent within a family. The opacities can be nuclear, sutural, stellate cortical, lamellar, cortical, nuclear embryonic, Y-sutural, punctate cortical, congenital or with juvenile- and adult-onset.
  • 序列相似性Belongs to the intermediate filament family.
  • 细胞定位Membrane. Cytoplasm. Cytoplasm > cytoskeleton. Membrane- and cytoskeleton-associated.
  • Information by UniProt
  • 数据库链接
  • 别名
    • 49 kDa cytoskeletal protein antibody
    • Beaded filament protein CP49 antibody
    • Beaded filament structural protein 2 antibody
    • Beaded filament structural protein 2, phakinin antibody
    • Bfps2, Cytoskeletal protein, 49 kD antibody
    • BFSP2 antibody
    • BFSP2_HUMAN antibody
    • CP47 antibody
    • CP49 antibody
    • Lens fiber cell beaded filament protein CP 47 antibody
    • Lens fiber cell beaded filament protein CP 49 antibody
    • Lens intermediate filament-like light antibody
    • LIFL-L antibody
    • MGC142078 antibody
    • MGC142080 antibody
    • Phakinin antibody
    • PHAKOSIN antibody
    see all

Anti-BFSP2 antibody 图像

  • ab122476 staining BFSP2 in paraffin-embedded Human lateral ventricle tissue by Immunohistochemistry.
  • ab122476 at 4 µg/ml staining BFSP2 in PFA/Triton X-100 fixed/permeabilized A431 cells by Immunofluorescence (green).

Anti-BFSP2 antibody (ab122476)参考文献

ab122476 has not yet been referenced specifically in any publications.

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