Anti-beta Tubulin抗体[2-28-33] (ab121095)

概述

  • 产品名称Anti-beta Tubulin抗体[2-28-33]
    参阅全部 beta Tubulin 一抗
  • 描述
    小鼠单克隆抗体[2-28-33] to beta Tubulin
  • 经测试应用适用于: IHC-Pmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Beta Tubulin isolated from Sarkosyl-resistant ribbons from Strongylocentrouts purpuratus ( Sea urchin) sperm axonemes.

  • 阳性对照
    • Breast carcinoma
  • 常规说明


    Excellent as a protein loading control antibody.

性能

应用

Our Abpromise guarantee covers the use of ab121095 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P Use at an assay dependent concentration.

靶标

  • 功能Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain.
  • 组织特异性Ubiquitously expressed with highest levels in spleen, thymus and immature brain.
  • 序列相似性Belongs to the tubulin family.
  • 结构域The highly acidic C-terminal region may bind cations such as calcium.
  • 翻译后修饰Some glutamate residues at the C-terminus are polyglutamylated. This modification occurs exclusively on glutamate residues and results in polyglutamate chains on the gamma-carboxyl group. Also monoglycylated but not polyglycylated due to the absence of functional TTLL10 in human. Monoglycylation is mainly limited to tubulin incorporated into axonemes (cilia and flagella) whereas glutamylation is prevalent in neuronal cells, centrioles, axonemes, and the mitotic spindle. Both modifications can coexist on the same protein on adjacent residues, and lowering glycylation levels increases polyglutamylation, and reciprocally. The precise function of such modifications is still unclear but they regulate the assembly and dynamics of axonemal microtubules.
  • 细胞定位Cytoplasm > cytoskeleton.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Beta 4 tubulin antibody
    • Beta 5 tubulin antibody
    • BetaTubulin antibody
    • TBB5_HUMAN antibody
    • TUBB antibody
    • TUBB2 antibody
    • TUBB2A antibody
    • TUBB5 antibody
    • tubulin beta 2A antibody
    • Tubulin beta chain antibody
    • Tubulin beta-5 chain antibody
    see all

Anti-beta Tubulin antibody [2-28-33] (ab121095)参考文献

ab121095 has not yet been referenced specifically in any publications.

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