Anti-beta Synuclein抗体,prediluted (ab15533)

概述

  • 产品名称
    Anti-beta Synuclein抗体,prediluted
    参阅全部 beta Synuclein 一抗
  • 描述
    兔多克隆抗体to beta Synuclein,prediluted
  • 宿主
    Rabbit
  • 特异性
    This antibody is specific for beta synuclein and does not cross react with alpha or gamma synuclein. Stains neuronal cytosol and presynaptic terminals.
  • 经测试应用
    适用于: IHC-Pmore details
  • 种属反应性
    与反应: Human
    预测可用于: Rat
  • 免疫原

    Synthetic peptide (unfortunately, the amino acid sequence is considered to be commercially sensitive) (Human) (C terminal).

  • 阳性对照
    • Brain.

性能

应用

Our Abpromise guarantee covers the use of ab15533 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P
  • 应用说明
    IHC-P: Ready to use for 10 minutes at room temperature. No special pretreatment is required for the immunohistochemical staining of formalin/paraffin tissues.

    Not tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能
      Non-amyloid component of senile plaques found in Alzheimer disease. Could act as a regulator of SNCA aggregation process. Protects neurons from staurosporine and 6-hydroxy dopamine (6OHDA)-stimulated caspase activation in a p53/TP53-dependent manner. Contributes to restore the SNCA anti-apoptotic function abolished by 6OHDA. Not found in the Lewy bodies associated with Parkinson disease.
    • 组织特异性
      Expressed predominantly in brain; concentrated in presynaptic nerve terminals.
    • 序列相似性
      Belongs to the synuclein family.
    • 翻译后修饰
      Phosphorylated. Phosphorylation by G-protein coupled receptor kinases (GRK) is more efficient than phosphorylation by CK1, CK2 and CaM-kinase II.
    • 细胞定位
      Cytoplasm.
    • Information by UniProt
    • 数据库链接
    • 别名
      • 14 kDa brain-specific protein antibody
      • Beta-synuclein antibody
      • Phosphoneuroprotein 14 antibody
      • PNP14 antibody
      • Sncb antibody
      • Synuclein beta antibody
      • SYUB_HUMAN antibody
      see all

    图片

    • ab15533 staining beta Synuclein in human brain by Immunohistochemistry (FFPE-sections).

    文献

    ab15533 has not yet been referenced specifically in any publications.

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