The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
应用说明IHC-P: Ready to use for 10 minutes at room temperature. No special pretreatment is required for the immunohistochemical staining of formalin/paraffin tissues.
Not tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
功能Non-amyloid component of senile plaques found in Alzheimer disease. Could act as a regulator of SNCA aggregation process. Protects neurons from staurosporine and 6-hydroxy dopamine (6OHDA)-stimulated caspase activation in a p53/TP53-dependent manner. Contributes to restore the SNCA anti-apoptotic function abolished by 6OHDA. Not found in the Lewy bodies associated with Parkinson disease.
组织特异性Expressed predominantly in brain; concentrated in presynaptic nerve terminals.
序列相似性Belongs to the synuclein family.
翻译后修饰Phosphorylated. Phosphorylation by G-protein coupled receptor kinases (GRK) is more efficient than phosphorylation by CK1, CK2 and CaM-kinase II.