Anti-beta Synuclein抗体(ab6164)

概述

  • 产品名称Anti-beta Synuclein抗体
    参阅全部 beta Synuclein 一抗
  • 描述
    羊多克隆抗体to beta Synuclein
  • 特异性Cross reactivity: This antibody is known to react with rat and human and other rodents. Cross reactivity with other species has not been tested yet.
  • 经测试应用适用于: IHC-P, IHC-Frmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide IEPLMEPEGESYEDPPQE corresponds to the carboxy terminal sequence of human beta-synuclein (108-125) and coupled to diphtheria toxoid via a cysteine residue attached to the C- terminal. The conjugate was cross-linked by maleimidocaproyl-N-hydroxy succinimide.

性能

应用

Our Abpromise guarantee covers the use of ab6164 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P
IHC-Fr
  • 应用说明Immunohistochemistry: 1 ug/ml
    Western Blot: Not tested.
    Immunoblot: Not tested.
    1 site ELISA: Not tested.
    Biological Inhibition: Not tested.
  • 靶标

    • 功能Non-amyloid component of senile plaques found in Alzheimer disease. Could act as a regulator of SNCA aggregation process. Protects neurons from staurosporine and 6-hydroxy dopamine (6OHDA)-stimulated caspase activation in a p53/TP53-dependent manner. Contributes to restore the SNCA anti-apoptotic function abolished by 6OHDA. Not found in the Lewy bodies associated with Parkinson disease.
    • 组织特异性Expressed predominantly in brain; concentrated in presynaptic nerve terminals.
    • 序列相似性Belongs to the synuclein family.
    • 翻译后修饰Phosphorylated. Phosphorylation by G-protein coupled receptor kinases (GRK) is more efficient than phosphorylation by CK1, CK2 and CaM-kinase II.
    • 细胞定位Cytoplasm.
    • Information by UniProt
    • 数据库链接
    • 别名
      • 14 kDa brain-specific protein antibody
      • Beta-synuclein antibody
      • Phosphoneuroprotein 14 antibody
      • PNP14 antibody
      • Sncb antibody
      • Synuclein beta antibody
      • SYUB_HUMAN antibody
      see all

    Anti-beta Synuclein antibody (ab6164)参考文献

    ab6164 has not yet been referenced specifically in any publications.

    Product Wall

    Ab6164 is stored in 5mM Tris-HCl, 0.9% NaCl. Please contact us again if you have any additional questions.

    All of the information we have for each of the anti-human-synuclein antibodies in our catalog is on the online datasheets. We are not aware of studies where they might have been used to detect relative levels of synuclein expression in leukocytes.

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"