Anti-beta Synuclein抗体(ab53167)

概述

  • 产品名称Anti-beta Synuclein抗体
    参阅全部 beta Synuclein 一抗
  • 描述
    兔多克隆抗体to beta Synuclein
  • 特异性ab53167 detects endogenous levels of total beta Synuclein protein.
  • 经测试应用适用于: WB, ELISAmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat
  • 免疫原

    A synthetic peptide derived from human beta Synuclein.

  • 阳性对照
    • HeLa cell extracts.

性能

应用

Our Abpromise guarantee covers the use of ab53167 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500 - 1/1000. Detects a band of approximately 14 kDa (predicted molecular weight: 14 kDa).
ELISA 1/5000.

靶标

  • 功能Non-amyloid component of senile plaques found in Alzheimer disease. Could act as a regulator of SNCA aggregation process. Protects neurons from staurosporine and 6-hydroxy dopamine (6OHDA)-stimulated caspase activation in a p53/TP53-dependent manner. Contributes to restore the SNCA anti-apoptotic function abolished by 6OHDA. Not found in the Lewy bodies associated with Parkinson disease.
  • 组织特异性Expressed predominantly in brain; concentrated in presynaptic nerve terminals.
  • 序列相似性Belongs to the synuclein family.
  • 翻译后修饰Phosphorylated. Phosphorylation by G-protein coupled receptor kinases (GRK) is more efficient than phosphorylation by CK1, CK2 and CaM-kinase II.
  • 细胞定位Cytoplasm.
  • Information by UniProt
  • 数据库链接
  • 别名
    • 14 kDa brain-specific protein antibody
    • Beta-synuclein antibody
    • Phosphoneuroprotein 14 antibody
    • PNP14 antibody
    • Sncb antibody
    • Synuclein beta antibody
    • SYUB_HUMAN antibody
    see all

Anti-beta Synuclein antibody 图像

  • All lanes : Anti-beta Synuclein antibody (ab53167) at 1/500 dilution

    Lane 1 : HeLa cell extract
    Lane 2 : HeLa cell extract with immunising peptide


    Predicted band size : 14 kDa
    Observed band size : 14 kDa

Anti-beta Synuclein antibody (ab53167)参考文献

ab53167 has not yet been referenced specifically in any publications.

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