Anti-beta glucuronidase (GUSB)抗体(ab103112)

概述

  • 产品名称Anti-beta glucuronidase (GUSB)抗体
    参阅全部 beta glucuronidase (GUSB) 一抗
  • 描述
    兔多克隆抗体to beta glucuronidase (GUSB)
  • 经测试应用适用于: WB, IHC-Pmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide conjugated to KLH, corresponding to a region within internal sequence amino acids 341-371 of Human beta glucuronidase (GUSB).

  • 阳性对照
    • WiDr, A2058, K562 cell line lysates and Human colon carcinoma tissue.

性能

应用

Our Abpromise guarantee covers the use of ab103112 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/100 - 1/500. Predicted molecular weight: 75 kDa.
IHC-P 1/50 - 1/100. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

靶标

  • 功能Plays an important role in the degradation of dermatan and keratan sulfates.
  • 疾病相关Defects in GUSB are the cause of mucopolysaccharidosis type 7 (MPS7) [MIM:253220]; also known as Sly syndrome. MPS7 is an autosomal recessive lysosomal storage disease characterized by inability to degrade glucuronic acid-containing glycosaminoglycans. The phenotype is highly variable, ranging from severe lethal hydrops fetalis to mild forms with survival into adulthood. Most patients with the intermediate phenotype show hepatomegaly, skeletal anomalies, coarse facies, and variable degrees of mental impairment.
    Note=Mucopolysaccharidosis type 7 is associated with non-immune hydrops fetalis, a generalized edema of the fetus with fluid accumulation in the body cavities due to non-immune causes. Non-immune hydrops fetalis is not a diagnosis in itself but a symptom, a feature of many genetic disorders, and the end-stage of a wide variety of disorders.
  • 序列相似性Belongs to the glycosyl hydrolase 2 family.
  • 翻译后修饰N-linked glycosylated with 3 to 4 oligosaccharide chains.
  • 细胞定位Lysosome.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Ac2-223 antibody
    • asd antibody
    • Beta G1 antibody
    • Beta glucuronidase antibody
    • Beta-G1 antibody
    • Beta-glucuronidase antibody
    • BG antibody
    • BGLR antibody
    • BGLR_HUMAN antibody
    • FLJ39445 antibody
    • Glucuronidase beta antibody
    • Gur antibody
    • Gus antibody
    • Gus-r antibody
    • Gus-s antibody
    • Gus-t antibody
    • Gus-u antibody
    • GUSB antibody
    • Gut antibody
    • MPS7 antibody
    see all

Anti-beta glucuronidase (GUSB) antibody 图像

  • All lanes : Anti-beta glucuronidase (GUSB) antibody (ab103112) at 1/100 dilution

    Lane 1 : WiDr cell lysate
    Lane 2 : A2058 cell lysate
    Lane 3 : K562 cell lysate

    Lysates/proteins at 35 µg per lane.


    Predicted band size : 75 kDa
  • ab103112 at 1/50 dilution staining beta glucuronidase (GUSB) in Human colon carcinoma by Immunohistochemistry Formalin-fixed, Paraffin-embedded tissue. Detection: DAB staining

Anti-beta glucuronidase (GUSB) antibody (ab103112)参考文献

ab103112 has not yet been referenced specifically in any publications.

Product Wall

We have not tested anti-beta-glucuronidase ab103112 for reactivity with mouse samples. Based on alignment of the antibody immunogen amino acid sequence with the sequence of mouse beta glucuronidase, reactivity is unlikely.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"