Anti-beta Dystroglycan抗体(ab103905)

概述

  • 产品名称Anti-beta Dystroglycan抗体
    参阅全部 beta Dystroglycan 一抗
  • 描述
    山羊多克隆抗体to beta Dystroglycan
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Mouse, Rat, Human
    预测可用于: Rabbit, Cow, Dog
  • 免疫原

    Synthetic peptide:

    C-HVGKHEYFMHATDK

    , corresponding to internal sequence amino acids 569-582 of Human beta Dystroglycan (NP_004384.3).

  • 阳性对照
    • Human Skeletal Muscle lysates.
  • 常规说明Reported variants represent identical protein: NP_001159400.1, NP_004384.3.

性能

应用

Our Abpromise guarantee covers the use of ab103905 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 0.1 - 0.3 µg/ml. Predicted molecular weight: 97 kDa.

靶标

  • 相关性Dystroglycans are essential elements of the neuromuscular junction (NMJ). The gene for dystroglycan is expressed as a precursor protein that is post translationally cleaved into a 156 kDa extracellular peripheral membrane protein called alpha dystroglycan and a 43 kDa transmembrane protein, beta dystroglycan. The latter protein contains a PPxY motif that promotes binding to WW domain containing proteins, such as utrophin and dystrophin. Phosphorylation at tyrosine 892 within the PPxY motif may regulate c Src interactions with beta dystroglycan, as well as inhibit interactions with WW domain proteins. In skeletal muscle, beta dystroglycan is normally localized to the plasma membrane, however phosphorylation of Tyr892 leads to localization of beta dystroglycan to endosomal compartments along with c Src. Thus, phosphorylation at Tyr892 may have important roles in altering the localization of beta dystroglycan during NMJ formation.
  • 细胞定位Type I membrane protein.
  • 数据库链接
  • 别名
    • 156DAG antibody
    • A3a antibody
    • AGRNR antibody
    • Beta DG antibody
    • Beta dystroglycan antibody
    • DAG 1 antibody
    • DAG1 antibody
    • Dystroglycan antibody
    • Dystrophin associated glycoprotein 1 antibody
    see all

Anti-beta Dystroglycan antibody 图像

  • Anti-beta Dystroglycan antibody (ab103905) at 0.2 µg/ml + Human Skeletal Muscle lysate at 35 µg

    Predicted band size : 97 kDa
  • All lanes : Anti-beta Dystroglycan antibody (ab103905) at 0.1 µg/ml

    Lane 1 : Mouse Skeletal Muscule Lysate in RIPA buffer
    Lane 2 : Rat Skeletal Muscule Lysate in RIPA buffer

    Lysates/proteins at 35 µg per lane.

    Developed using the ECL technique

    Predicted band size : 97 kDa

Anti-beta Dystroglycan antibody (ab103905)参考文献

ab103905 has not yet been referenced specifically in any publications.

Product Wall

Thank you for your inquiry.

I can confirm that we do not know of any publication using the above mentioned antibodies. I would like to reassure you that we do guarantee our product for all species and applications stated on the respective dat...

Read More

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"