Anti-beta amyloid 1-43抗体[9C4] (ab22258)

概述

  • 产品名称Anti-beta amyloid 1-43抗体[9C4]
  • 描述
    小鼠单克隆抗体[9C4] to beta amyloid 1-43
  • 特异性Reactive to the c-terminus of beta amyloid and specific for the isoform ending at the 43rd amino acid.
  • 经测试应用适用于: WB, ELISA, IHC-Pmore details
  • 种属反应性
    与反应: Mouse, Human
  • 免疫原

    Synthetic peptide corresponding to Human beta amyloid 1-43 (C terminal).

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • 存储溶液Preservative: None
    Constituents: PBS
  • Concentration information loading...
  • 纯度Protein A purified
  • 克隆单克隆
  • 克隆编号9C4
  • 骨髓瘤unknown
  • 同种型IgG1
  • 轻链类型unknown
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab22258 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/100 - 1/1000. Predicted molecular weight: 87 kDa.
ELISA 1/500.
IHC-P Use at an assay dependent concentration. Retrieve antigens with 70% Formic acid for 10-30 minutes at room temperature before commencing with IHC staining protocol.

靶标

  • 相关性The cerebral and vascular plaques associated with Alzheimer's disease are mainly composed of Amyloid beta peptides. beta Amyloid is derived from cleavage of the Amyloid precursor protein and varies in length from 39 to 43 amino acids. beta Amyloid [1-40], beta Amyloid [1-42], and beta Amyloid [1-43] peptides result from cleavage of Amyloid precursor protein after residues 40, 42, and 43, respectively. The cleavage takes place by gamma-secretase during the last Amyloid precursor protein processing step. beta Amyloid [1-40], beta Amyloid [1-42], and beta Amyloid [1-43] peptides are major constituents of the plaques and tangles that occur in Alzheimer's disease. beta Amyloid antibodies and peptides have been developed as tools for elucidating the biology of Alzheimer's disease.
  • 细胞定位Plasma membrane
  • 数据库链接
  • 别名
    • ABPP antibody
    • APPI antibody
    • CVAP antibody
    • PN-II antibody
    • PreA4 antibody
    • Protease nexin-II antibody
    see all

Anti-beta amyloid 1-43 antibody [9C4] (ab22258)参考文献

ab22258 has not yet been referenced specifically in any publications.

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