Anti-beta 2 Microglobulin抗体[F21-21] (FITC) (ab24886)

概述

  • 产品名称Anti-beta 2 Microglobulin抗体[F21-21] (FITC)
    参阅全部 beta 2 Microglobulin 一抗
  • 描述
    小鼠单克隆抗体[F21-21] to beta 2 Microglobulin (FITC)
  • 偶联物FITC. Ex: 493nm, Em: 528nm
  • 特异性ab24886 recognises Beta 2 Microglobulin of MHC Class I molecules.
  • 经测试应用适用于: WB, Flow Cyt, IPmore details
  • 种属反应性
    与反应: Chicken, Turkey
  • 免疫原

    The details of the immunogen for this antibody are not available.

  • 阳性对照
    • Chicken peripheral blood mononuclear cells.

性能

应用

Our Abpromise guarantee covers the use of ab24886 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use at an assay dependent concentration. Predicted molecular weight: 14 kDa.
Flow Cyt Use 1µg for 106 cells. ab106163-Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody.
IP Use at an assay dependent concentration.
AP Use at an assay dependent concentration.

ab24886 can be used also for immunoaffinity chromatography experiments.

靶标

  • 功能Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.
  • 疾病相关Defects in B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP) [MIM:241600]. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation.
    Note=Beta-2-microglobulin may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. Persistently high beta(2)-microglobulin serum levels lead to amyloidosis in patients on long-term hemodialysis.
  • 序列相似性Belongs to the beta-2-microglobulin family.
    Contains 1 Ig-like C1-type (immunoglobulin-like) domain.
  • 翻译后修饰Glycation of Ile-21 is observed in long-term hemodialysis patients.
  • 细胞定位Secreted. Detected in serum and urine.
  • Information by UniProt
  • 别名
    • B2M antibody
    • B2MG_HUMAN antibody
    • Beta 2 microglobin antibody
    • Beta 2 microglobulin antibody
    • Beta 2 microglobulin precursor antibody
    • Beta chain of mhc class 1 proteins antibody
    • Beta chain of MHC class I molecules antibody
    • Beta-2-microglobulin form pI 5.3 antibody
    • CDABP0092 antibody
    • Hdcma22p antibody
    see all

Anti-beta 2 Microglobulin antibody [F21-21] (FITC) 图像

  • Chicken peripheral blood mononuclear cells were double stained with ab24886 (1 µg/106 cells) and mouse anti chicken CD3 PE. Small lymphocytes were gated using light scatter criteria and analyzed on a flow cytometer.

Anti-beta 2 Microglobulin antibody [F21-21] (FITC) (ab24886)参考文献

ab24886 has not yet been referenced specifically in any publications.

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