Anti-beta 2 Microglobulin抗体[F21-21] (Biotin) (ab25160)

概述

  • 产品名称Anti-beta 2 Microglobulin抗体[F21-21] (Biotin)
    参阅全部 beta 2 Microglobulin 一抗
  • 描述
    小鼠单克隆抗体[F21-21] to beta 2 Microglobulin (Biotin)
  • 偶联物Biotin
  • 特异性ab25160 recognises the ß2-microglobulin subunit of MHC Class I molecules
  • 经测试应用适用于: Other, Flow Cyt, IP, WBmore details
  • 种属反应性
    与反应: Chicken, Turkey
  • 免疫原

    The details of the immunogen for this antibody are not available.

性能

应用

Our Abpromise guarantee covers the use of ab25160 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
Other
Flow Cyt
IP
WB
AP
  • 应用说明AP: Use at an assay dependent dilution.
    Flow Cyt: Use 1µg for 106 cells.
    IP: Use at an assay dependent dilution.
    WB: Use at an assay dependent dilution. Predicted molecular weight: 13 kDa.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.
    • 疾病相关Defects in B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP) [MIM:241600]. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation.
      Note=Beta-2-microglobulin may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. Persistently high beta(2)-microglobulin serum levels lead to amyloidosis in patients on long-term hemodialysis.
    • 序列相似性Belongs to the beta-2-microglobulin family.
      Contains 1 Ig-like C1-type (immunoglobulin-like) domain.
    • 翻译后修饰Glycation of Ile-21 is observed in long-term hemodialysis patients.
    • 细胞定位Secreted. Detected in serum and urine.
    • Information by UniProt
    • 别名
      • B2M antibody
      • B2MG_HUMAN antibody
      • Beta 2 microglobin antibody
      • Beta 2 microglobulin antibody
      • Beta 2 microglobulin precursor antibody
      • Beta chain of mhc class 1 proteins antibody
      • Beta chain of MHC class I molecules antibody
      • Beta-2-microglobulin form pI 5.3 antibody
      • CDABP0092 antibody
      • Hdcma22p antibody
      see all

    Anti-beta 2 Microglobulin antibody [F21-21] (Biotin) (ab25160)参考文献

    ab25160 has not yet been referenced specifically in any publications.

    Product Wall

    There are currently no Abreviews or Questions for ab25160.
    Please use the links above to contact us or submit feedback about this product.

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"