Anti-beta 2 Microglobulin抗体- C-terminal (ab80071)

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概述

  • 产品名称
    Anti-beta 2 Microglobulin抗体- C-terminal
    参阅全部 beta 2 Microglobulin 一抗
  • 描述
    兔多克隆抗体to beta 2 Microglobulin - C-terminal
  • 宿主
    Rabbit
  • 经测试应用
    适用于: ELISA, IHC-Pmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide from the C terminal region of Human beta 2 Microglobulin, conjugated to KLH.

  • 阳性对照
    • Human lung carcinoma tissue.

性能

应用

Our Abpromise guarantee covers the use of ab80071 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ELISA 1/1000.
IHC-P 1/10 - 1/50.

靶标

  • 功能
    Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.
  • 疾病相关
    Defects in B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP) [MIM:241600]. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation.
    Note=Beta-2-microglobulin may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. Persistently high beta(2)-microglobulin serum levels lead to amyloidosis in patients on long-term hemodialysis.
  • 序列相似性
    Belongs to the beta-2-microglobulin family.
    Contains 1 Ig-like C1-type (immunoglobulin-like) domain.
  • 翻译后修饰
    Glycation of Ile-21 is observed in long-term hemodialysis patients.
  • 细胞定位
    Secreted. Detected in serum and urine.
  • Information by UniProt
  • 数据库链接
    • 别名
      • B2M antibody
      • B2MG_HUMAN antibody
      • Beta 2 microglobin antibody
      • Beta 2 microglobulin antibody
      • Beta 2 microglobulin precursor antibody
      • Beta chain of mhc class 1 proteins antibody
      • Beta chain of MHC class I molecules antibody
      • Beta-2-microglobulin form pI 5.3 antibody
      • CDABP0092 antibody
      • Hdcma22p antibody
      • IMD43 antibody
      see all

    图片

    • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-beta 2 Microglobulin antibody - C-terminal (ab80071)
      Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-beta 2 Microglobulin antibody - C-terminal (ab80071)
      Immunohistochemistry analysis of formalin-fixed, paraffin-embedded Human lung carcinoma tissue using ab80068 at a 1/10 dilution, with a peroxidase-conjugated secondary antibody, followed by DAB staining.
    • Western blot - Anti-beta 2 Microglobulin antibody - C-terminal (ab80071)
      Western blot - Anti-beta 2 Microglobulin antibody - C-terminal (ab80071)
      All lanes : Anti-beta 2 Microglobulin antibody - C-terminal (ab80071) at 1/500 dilution

      Lane 1 : Non-transfected 293 cell lysates
      Lane 2 : Beta 2 Microglobulin transfected 293 cell lysates

      Lysates/proteins at 2 µg per lane.

    文献

    ab80071 has not yet been referenced specifically in any publications.

    发表研究结果有使用 ab80071？请让我们知道，以便我们可以引用本数据表中的参考文章。

    客户评价及客户问答

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    1 Review or Q&A

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    Customer kindly called to discuss using our beta 2 Microglobulin products in ELISA on porcine tissues.

    Thank you for contacting Abcam. I have been in contact with the labs about our kit and also have some additional details regarding our other Beta-2-Microglobulin products reactivity with porcine.

    For our kits:

    Regardingab99977:Unf...

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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