Anti-beta 2 Microglobulin抗体(ab98327)

概述

  • 产品名称Anti-beta 2 Microglobulin抗体
    参阅全部 beta 2 Microglobulin 一抗
  • 描述
    兔多克隆抗体to beta 2 Microglobulin
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Rabbit, Horse, Guinea pig, Cat, Dog, African Green Monkey, Spider Monkey
  • 免疫原

    Synthetic peptide corresponding to a region within N terminal amino acids 1-50 (MSRSVALAVL ALLSLSGLEA IQRTPKIQVY SRHPAENGKS NFLNCYVSGF) of Human beta 2 Microglobulin (NP_004039).

  • 阳性对照
    • Fetal thymus lysate

性能

应用

Our Abpromise guarantee covers the use of ab98327 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 14 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

靶标

  • 功能Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.
  • 疾病相关Defects in B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP) [MIM:241600]. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation.
    Note=Beta-2-microglobulin may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. Persistently high beta(2)-microglobulin serum levels lead to amyloidosis in patients on long-term hemodialysis.
  • 序列相似性Belongs to the beta-2-microglobulin family.
    Contains 1 Ig-like C1-type (immunoglobulin-like) domain.
  • 翻译后修饰Glycation of Ile-21 is observed in long-term hemodialysis patients.
  • 细胞定位Secreted. Detected in serum and urine.
  • Information by UniProt
  • 数据库链接
  • 别名
    • B2M antibody
    • B2MG_HUMAN antibody
    • Beta 2 microglobin antibody
    • Beta 2 microglobulin antibody
    • Beta 2 microglobulin precursor antibody
    • Beta chain of mhc class 1 proteins antibody
    • Beta chain of MHC class I molecules antibody
    • Beta-2-microglobulin form pI 5.3 antibody
    • CDABP0092 antibody
    • Hdcma22p antibody
    see all

Anti-beta 2 Microglobulin antibody 图像

  • Anti-beta 2 Microglobulin antibody (ab98327) at 1 µg/ml (in 5% skim milk / PBS buffer) + Human fetal thymus lysate at 10 µg

    Secondary
    HRP conjugated anti-Rabbit IgG at 1/50000 dilution

    Predicted band size : 14 kDa

Anti-beta 2 Microglobulin antibody (ab98327)参考文献

ab98327 has not yet been referenced specifically in any publications.

Product Wall

In review of the immunogen sequence used for creating ab75853 I see this sequence share only 69.2% identity with rabbit beta-2-microglobulin. Generally we do not expect reactivity below 80%. Overall I have found that the sequence homologies of human...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"