Anti-BCRP/ABCG2抗体[BXP-9] (ab24114)


  • 产品名称
    参阅全部 BCRP/ABCG2 一抗
  • 描述
    大鼠单克隆抗体[BXP-9] to BCRP/ABCG2
  • 宿主
  • 经测试应用
    适用于: IHC-P, ICC, IHC-Fr, WB, Flow Cytmore details
  • 种属反应性
    与反应: Mouse
    不与反应: Human
  • 免疫原

    A fusion protein containing the E. coli maltose binding protein and a fragment of the mouse bcrp protein corresponding to amino acids 221-394.

  • 阳性对照
    • bone marrow and kidney tissue



Our Abpromise guarantee covers the use of ab24114 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P Use at an assay dependent concentration. PubMed: 20133811
ICC 1/20 - 1/50. Acetone fixed cytospin preparations
IHC-Fr 1/20. Fix with acetone and use biotin-streptavidin amplification.
WB 1/20 - 1/50. Predicted molecular weight: 70 kDa.
Flow Cyt Use at an assay dependent concentration.

ab18407 - Rat monoclonal IgG1, is suitable for use as an isotype control with this antibody.



  • 功能
    Xenobiotic transporter that may play an important role in the exclusion of xenobiotics from the brain. May be involved in brain-to-blood efflux. Appears to play a major role in the multidrug resistance phenotype of several cancer cell lines. When overexpressed, the transfected cells become resistant to mitoxantrone, daunorubicin and doxorubicin, display diminished intracellular accumulation of daunorubicin, and manifest an ATP-dependent increase in the efflux of rhodamine 123.
  • 组织特异性
    Highly expressed in placenta. Low expression in small intestine, liver and colon.
  • 序列相似性
    Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.
    Contains 1 ABC transmembrane type-2 domain.
    Contains 1 ABC transporter domain.
  • 翻译后修饰
    Glycosylation-deficient ABCG2 is normally expressed and functional.
  • 细胞定位
    Cell membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • ABC transporter antibody
    • ABC15 antibody
    • ABCG 2 antibody
    • ABCG2 antibody
    • ABCG2_HUMAN antibody
    • ABCP antibody
    • ATP binding cassette sub family G (WHITE) member 2 antibody
    • ATP binding cassette transporter G2 antibody
    • ATP-binding cassette sub-family G member 2 antibody
    • BCRP antibody
    • BCRP1 antibody
    • BMDP antibody
    • Breast cancer resistance protein antibody
    • CD338 antibody
    • CDw338 antibody
    • CDw338 antigen antibody
    • EST157481 antibody
    • GOUT1 antibody
    • MGC102821 antibody
    • Mitoxantrone resistance associated protein antibody
    • Mitoxantrone resistance-associated protein antibody
    • MRX antibody
    • Multi drug resistance efflux transport ATP binding cassette sub family G (WHITE) member 2 antibody
    • MXR antibody
    • MXR1 antibody
    • Placenta specific ATP binding cassette transporter antibody
    • Placenta specific MDR protein antibody
    • Placenta-specific ATP-binding cassette transporter antibody
    • UAQTL1 antibody
    see all


This product has been referenced in:
  • Gouveia RM  et al. Controlling the 3D architecture of Self-Lifting Auto-generated Tissue Equivalents (SLATEs) for optimized corneal graft composition and stability. Biomaterials 121:205-219 (2017). IF ; Human . Read more (PubMed: 28092777) »
  • Lv L  et al. Effect of miR-155 knockdown on the reversal of doxorubicin resistance in human lung cancer A549/dox cells. Oncol Lett 11:1161-1166 (2016). Read more (PubMed: 26893712) »

See all 5 Publications for this product


I am sorry this product did not perform as stated on the datasheet and for the inconvenience this has caused. As requested, I have issued a free of charge replacement for one vial of ab24115.

To check the status of the order please contact o...

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Thank you for your enquiry. The antibodies were tested by FACS on bone marrow and kidney tissue, but we have no data or a publication available. We know that one customer has compared the two and found that ab24115 was more sensitive than ab241...

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The immunogen was raised against amino acids 221-394 of the Mouse Protein and according to Swiss Prot the amino acids 1-393 are cytoplasmic so the antibody recognizes the intracellular portion of the protein. We expect the FACS protocol to require perm...

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