Anti-BCRP/ABCG2抗体[BXP-34] (ab3379)


  • 产品名称
    参阅全部 BCRP/ABCG2 一抗
  • 描述
    小鼠单克隆抗体[BXP-34] to BCRP/ABCG2
  • 特异性
    This antibody does not cross react with the human MDR1, MRP1, MRP2 or MRP5 gene products.
  • 经测试应用
    适用于: ICC, IHC-Frmore details
    不适用于: WB
  • 种属反应性
    与反应: Human
  • 免疫原

    BCRP over-expressing cell line MCF 7 MR.

  • 表位
    Internal epitope.
  • 常规说明

    Breast Cancer Resistance Protein (BCRP) is a 70 kDa ATP-Binding Cassette membrane transport protein involved in multidrug resistance. BCRP may be over-expressed in cancer cell lines selected with doxorubicin / verapamil, topotecan or mitoxantrone.



Our Abpromise guarantee covers the use of ab3379 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ICC Use at an assay dependent concentration.
IHC-Fr Use at an assay dependent concentration.
  • 应用说明
    Is unsuitable for WB.
  • 靶标

    • 功能
      Xenobiotic transporter that may play an important role in the exclusion of xenobiotics from the brain. May be involved in brain-to-blood efflux. Appears to play a major role in the multidrug resistance phenotype of several cancer cell lines. When overexpressed, the transfected cells become resistant to mitoxantrone, daunorubicin and doxorubicin, display diminished intracellular accumulation of daunorubicin, and manifest an ATP-dependent increase in the efflux of rhodamine 123.
    • 组织特异性
      Highly expressed in placenta. Low expression in small intestine, liver and colon.
    • 序列相似性
      Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.
      Contains 1 ABC transmembrane type-2 domain.
      Contains 1 ABC transporter domain.
    • 翻译后修饰
      Glycosylation-deficient ABCG2 is normally expressed and functional.
    • 细胞定位
      Cell membrane.
    • Information by UniProt
    • 数据库链接
    • 别名
      • ABC transporter antibody
      • ABC15 antibody
      • ABCG 2 antibody
      • ABCG2 antibody
      • ABCG2_HUMAN antibody
      • ABCP antibody
      • ATP binding cassette sub family G (WHITE) member 2 antibody
      • ATP binding cassette transporter G2 antibody
      • ATP-binding cassette sub-family G member 2 antibody
      • BCRP antibody
      • BCRP1 antibody
      • BMDP antibody
      • Breast cancer resistance protein antibody
      • CD338 antibody
      • CDw338 antibody
      • CDw338 antigen antibody
      • EST157481 antibody
      • GOUT1 antibody
      • MGC102821 antibody
      • Mitoxantrone resistance associated protein antibody
      • Mitoxantrone resistance-associated protein antibody
      • MRX antibody
      • Multi drug resistance efflux transport ATP binding cassette sub family G (WHITE) member 2 antibody
      • MXR antibody
      • MXR1 antibody
      • Placenta specific ATP binding cassette transporter antibody
      • Placenta specific MDR protein antibody
      • Placenta-specific ATP-binding cassette transporter antibody
      • UAQTL1 antibody
      see all


    This product has been referenced in:
    • Nagy BM  et al. Lack of ABCG2 Leads to Biventricular Dysfunction and Remodeling in Response to Hypoxia. Front Physiol 8:98 (2017). ICC/IF ; Mouse . Read more (PubMed: 28270772) »
    • Scheffer GL  et al. Breast cancer resistance protein is localized at the plasma membrane in mitoxantrone- and topotecan-resistant cell lines. Cancer Res 60:2589-93 (2000). ICC/IF, IHC-Fr ; Human . Read more (PubMed: 10825126) »

    See all 2 Publications for this product


    Thank you for contacting us.

    I was unable to obtain the exact sequence of the peptide that was used as the immunogen for ab134707, and as far as we know, the epitope recognized by ab3379 has not been mapped. However, we do know that the immu...

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    Thank you for your inquiry.

    I have checked the immunogen sequences of the BCRP/ABCG2 and p53 antibodies we have that are tested in IHC-Fr with the rabbit sequences for these proteins.

    I am sorry to confirm that regrettably, the al...

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    The IgG concentration of ab3379 is approximately 0.25 mg/ml.