概述

  • 产品名称Anti-Bcr抗体
    参阅全部 Bcr 一抗
  • 描述
    兔多克隆抗体to Bcr
  • 经测试应用适用于: IHC-P, ICC/IF, IPmore details
    不适用于: Flow Cyt or WB
  • 种属反应性
    与反应: Human
    不与反应: Mouse, Rat
  • 免疫原

    Synthetic peptide within Human Bcr aa 1250-1350 (C terminal). The exact sequence is proprietary.

  • 阳性对照
    • Jurkat cell lysate, human lung carcinoma and HeLa cells.

性能

相关产品

应用

Our Abpromise guarantee covers the use of ab32523 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P
ICC/IF
IP
  • 应用说明ICC/IF: 1/250 - 1/500.
    IHC-P: 1/100 - 1/250.
    IP: 1/40.


    Is unsuitable for FACS or WB.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能GTPase-activating protein for RAC1 and CDC42. Promotes the exchange of RAC or CDC42-bound GDP by GTP, thereby activating them. Displays serine/threonine kinase activity.
    • 疾病相关Note=A chromosomal aberration involving BCR is a cause of chronic myeloid leukemia. Translocation t(9;22)(q34;q11) with ABL1. The translocation produces a BCR-ABL found also in acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL).
    • 序列相似性Contains 1 C2 domain.
      Contains 1 DH (DBL-homology) domain.
      Contains 1 PH domain.
      Contains 1 Rho-GAP domain.
    • 结构域The region involved in binding to ABL1 SH2-domain is rich in serine residues and needs to be Ser/Thr phosphorylated prior to SH2 binding. This region is essential for the activation of the ABL1 tyrosine kinase and transforming potential of the chimeric BCR-ABL oncogene.
      The DH domain is involved in interaction with CCPG1.
    • 翻译后修饰Autophosphorylated. Phosphorylated by FES/FPS on tyrosine residues, leading to down-regulation of the BCR kinase activity. Phosphorylation at Tyr-177 by HCK is important for interaction with GRB2.
    • Information by UniProt
    • 数据库链接
    • 别名
      • ALL antibody
      • bcr antibody
      • BCR/ABL FUSION GENE, INCLUDED antibody
      • BCR/FGFR1 chimera protein antibody
      • BCR/FGFR1 FUSION GENE, INCLUDED antibody
      • BCR/PDGFRA FUSION GENE, INCLUDED antibody
      • BCR_HUMAN antibody
      • BCR1 antibody
      • Breakpoint cluster region antibody
      • Breakpoint cluster region protein antibody
      • CML antibody
      • D22S11 antibody
      • D22S662 antibody
      • FGFR1/BCR chimera protein antibody
      • PHL antibody
      • Renal carcinoma antigen NY-REN-26 antibody
      see all

    Anti-Bcr antibody 图像

    • Immunohistochemical analysis of paraffin-embedded human lung carcinoma using ab32523 at 1/100 dilution.Immunohistochemical analysis of paraffin-embedded human lung carcinoma using ab32523 at 1/100 dilution.
    • Immunofluorescent staining of HeLa cells using ab32523 at 1/250 dilution.

    Anti-Bcr antibody (ab32523)参考文献

    ab32523 has not yet been referenced specifically in any publications.

    Product Wall

    There are currently no Abreviews or Questions for ab32523.
    Please use the links above to contact us or submit feedback about this product.

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"