概述

  • 产品名称
  • 描述
    小鼠多克隆抗体to BCOR
  • 经测试应用
    适用于: WB, ICC/IFmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Recombinant full length Human BCOR (short isoform, NP_065977.1)

  • 阳性对照
    • Human colon tissue lysate. HeLa cells.

性能

应用

Our Abpromise guarantee covers the use of ab88112 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 107 kDa.
ICC/IF Use a concentration of 10 µg/ml.

靶标

  • 功能
    Transcriptional corepressor. May specifically inhibit gene expression when recruited to promoter regions by sequence specific DNA-binding proteins such as BCL6 and MLLT3. This repression may be mediated at least in part by histone deacetylase activities which can associate with this corepressor. Involved in the repression of TFAP2A; impairs binding of BCL6 and KDM2B to TFAP2A promoter regions. Via repression of TFAP2A acts as a negative regulator of osteo-dentiogenic capacity in adult stem cells; the function implies inhibition of methylation on histone H3 'Lys-4' (H3K4me3) and 'Lys-36' (H3K36me2).
  • 组织特异性
    Ubiquitously expressed.
  • 疾病相关
    Defects in BCOR are the cause of microphthalmia syndromic type 2 (MCOPS2) [MIM:300166]. Microphthalmia is a clinically heterogeneous disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues (anophthalmia). In many cases, microphthalmia/anophthalmia occurs in association with syndromes that include non-ocular abnormalities. MCOPS2 is a very rare multiple congenital anomaly syndrome characterized by eye anomalies (congenital cataract, microphthalmia, or secondary glaucoma), facial abnormalities (long narrow face, high nasal bridge, pointed nose with cartilages separated at the tip, cleft palate, or submucous cleft palate), cardiac anomalies (atrial septal defect, ventricular septal defect, or floppy mitral valve) and dental abnormalities (canine radiculomegaly, delayed dentition, oligodontia, persistent primary teeth, or variable root length).
  • 序列相似性
    Belongs to the BCOR family.
    Contains 3 ANK repeats.
  • 细胞定位
    Nucleus.
  • Information by UniProt
  • 数据库链接
  • 别名
    • 5830466J11Rik antibody
    • 8430401K06Rik antibody
    • ANOP 2 antibody
    • ANOP2 antibody
    • BCL 6 co repressor antibody
    • BCL 6 corepressor antibody
    • BCL 6 interacting corepressor antibody
    • BCL-6 corepressor antibody
    • BCL6 co repressor antibody
    • BCL6 corepressor antibody
    • BCL6 interacting corepressor antibody
    • BCoR antibody
    • BCOR_HUMAN antibody
    • FLJ20285 antibody
    • FLJ38041 antibody
    • KIAA1575 antibody
    • MAA 2 antibody
    • MAA2 antibody
    • MCOPS 2 antibody
    • MCOPS2 antibody
    • MGC131961 antibody
    • MGC71031 antibody
    see all

Anti-BCOR antibody 图像

  • Anti-BCOR antibody (ab88112) at 1 µg/ml + Human colon tissue lysate at 50 µg

    Secondary
    Goat anti-Mouse IgG at 1/5000 dilution

    Predicted band size : 107 kDa
  • All lanes : Anti-BCOR antibody (ab88112) at 1 µg/ml

    Lane 1 : BCOR-transfected 293T cell lysate
    Lane 2 : untransfected 293T cell lysate

    Lysates/proteins at 25 µg per lane.

    Secondary
    Goat anti-Mouse IgG at 1/5000 dilution

    Predicted band size : 107 kDa
    Observed band size : 110 kDa (why is the actual band size different from the predicted?)
  • Immunofluorescence staining of BCOR in HeLa cells using ab88112 at 10 µg/ml followed by a fluorescein conjugated secondary antibody.

Anti-BCOR antibody (ab88112)参考文献

This product has been referenced in:
  • Paret C  et al. Activation of the basal cell carcinoma pathway in a patient with CNS HGNET-BCOR diagnosis: consequences for personalized targeted therapy. Oncotarget 7:83378-83391 (2016). WB ; Human . Read more (PubMed: 27825128) »
  • Roy A  et al. Recurrent internal tandem duplications of BCOR in clear cell sarcoma of the kidney. Nat Commun 6:8891 (2015). Human . Read more (PubMed: 26573325) »

See all 4 Publications for this product

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