概述

  • 产品名称Anti-BCMO1抗体
    参阅全部 BCMO1 一抗
  • 描述
    兔多克隆抗体to BCMO1
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide conjugated to KLH, corresponding to a region btween internal sequence amino acids 270-300 of Human BCMO1 (NP_059125.2).

  • 阳性对照
    • WiDr cell line lysates

性能

应用

Our Abpromise guarantee covers the use of ab107418 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/100 - 1/500. Predicted molecular weight: 63 kDa.

靶标

  • 功能Symmetrically cleaves beta-carotene into two molecules of retinal. The reaction proceeds in three stages, epoxidation of the 15,15'-double bond, hydration of the double bond leading to ring opening, and oxidative cleavage of the diol formed.
  • 组织特异性Highly expressed in retinal pigment epithelium. Also expressed in kidney, testis, liver, brain, small intestine and colon.
  • 通路Cofactor metabolism; retinol metabolism.
  • 疾病相关Defects in BCMO1 are the cause of autosomal dominant hypercarotenemia and vitamin A deficiency (ADHVAD) [MIM:115300]. Vitamin A is essential for normal embryonic development as well as normal physiological functions in children and adults. Hypercarotenemia is characterized by an excess carotene in the serum, but unlike excess vitamin A, carotene is non-toxic. So far, only a few cases of excess vitamin A have been reported. Individuals were thought to be vitamin A deficient due to an impairment in the conversion of carotenoids to retinal in the intestine.
  • 序列相似性Belongs to the carotenoid oxygenase family.
  • Information by UniProt
  • 数据库链接
  • 别名
    • BCDO antibody
    • BCDO1 antibody
    • BCDO1_HUMAN antibody
    • BCMO antibody
    • Bcmo1 antibody
    • BCO antibody
    • BCO1 antibody
    • Beta,beta-carotene 15,15'-monooxygenase antibody
    • beta-carotene 15,15'-monooxygenase 1 antibody
    • Beta-carotene dioxygenase 1 antibody
    • FLJ10730 antibody
    see all

Anti-BCMO1 antibody 图像

  • Anti-BCMO1 antibody (ab107418) at 1/100 dilution + WiDr cell line lysates at 35 µg

    Predicted band size : 63 kDa

Anti-BCMO1 antibody (ab107418)参考文献

ab107418 has not yet been referenced specifically in any publications.

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