概述

  • 产品名称Anti-BCMA抗体
    参阅全部 BCMA 一抗
  • 描述
    兔多克隆抗体to BCMA
  • 经测试应用适用于: ICC/IF, IHC-P, WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide (Human).

  • 阳性对照
    • Human spleen tissue lysate, K562 or U937 whole cell lysates.
  • 常规说明Stable for one year.


    Members in the TNF superfamily regulate immune responses and induce apoptosis. Two novel members in the TNF family were recently identified and designated BAFF/BLyS/TALL1/THANK/zTNF4 and April/TALL2, respectively. BAFF was characterized as a B cell activator since it induced B cell proliferation and immunoglobulin secretion. April regulates immunological and non immunological cell growth. Three receptors, BCMA (for B cell maturation protein), TACI, and BAFFR, for BAFF were recently identified. BCMA, like TACI, binds BAFF and April. BAFF and its receptors induce B cell development and survival, activate NF-kappaB and c-jun N-terminal kinase, and are involved in B cell associated autoimmune diseases.

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C. Avoid freeze / thaw cycle. Stable for 12 months at -20°C.
  • 存储溶液Preservative: 0.02% Sodium Azide
    Constituents: PBS
  • Concentration information loading...
  • 纯度Immunogen affinity purified
  • 纯化说明BCMA Antibody is affinity chromatography purified via peptide column.
  • Primary antibody说明Members in the TNF superfamily regulate immune responses and induce apoptosis. Two novel members in the TNF family were recently identified and designated BAFF/BLyS/TALL1/THANK/zTNF4 and April/TALL2, respectively. BAFF was characterized as a B cell activator since it induced B cell proliferation and immunoglobulin secretion. April regulates immunological and non immunological cell growth. Three receptors, BCMA (for B cell maturation protein), TACI, and BAFFR, for BAFF were recently identified. BCMA, like TACI, binds BAFF and April. BAFF and its receptors induce B cell development and survival, activate NF-kappaB and c-jun N-terminal kinase, and are involved in B cell associated autoimmune diseases.
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab5972 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ICC/IF Use a concentration of 20 µg/ml.
IHC-P Use a concentration of 10 µg/ml.
WB Use a concentration of 2 - 5 µg/ml. Predicted molecular weight: 20 kDa.Can be blocked with BCMA peptide (ab6087).

靶标

  • 功能Receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL. Promotes B-cell survival and plays a role in the regulation of humoral immunity. Activates NF-kappa-B and JNK.
  • 组织特异性Expressed in mature B-cells, but not in T-cells or monocytes.
  • 疾病相关Note=A chromosomal aberration involving TNFRSF17 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with IL2.
  • 序列相似性Contains 1 TNFR-Cys repeat.
  • 细胞定位Cell membrane. Endomembrane system. Perinuclear Golgi-like structures.
  • Information by UniProt
  • 数据库链接
  • 别名
    • B cell maturation antigen antibody
    • B cell maturation factor antibody
    • B cell maturation protein antibody
    • B-cell maturation protein antibody
    • BCM antibody
    • BCMA antibody
    • CD269 antibody
    • CD269 antigen antibody
    • TNFRSF17 antibody
    • TNR17_HUMAN antibody
    • Tumor necrosis factor receptor superfamily member 17 antibody
    see all

Anti-BCMA antibody 图像

  • Immunohistochemistry of BCMA in human spleen tissue with BCMA antibody at 5 µg/ml.



  • Predicted band size : 20 kDa
    Western blot analysis of BCMA in human spleen (A) tissue lysate, K562 (B), and U937 (C) cell lysates with ab5972 at 5 µg/ml. Western blot analysis of BCMA in human spleen (A) tissue lysate, K562 (B), and U937 (C) cell lysates with ab5972 at 5 µg/ml.
  • ab5972 at 10µg/ml staining BCMA in human spleen cells by IHC

  • Immunofluorescence of BCMA in Human Spleen cells using ab5972 at 10 ug/ml.

Anti-BCMA antibody (ab5972)参考文献

This product has been referenced in:
  • Müller N  et al. B Lymphocyte Stimulator (BLyS) Is Expressed in Human Adipocytes In Vivo and Is Related to Obesity but Not to Insulin Resistance. PLoS One 9:e94282 (2014). WB ; Human . Read more (PubMed: 24728308) »
  • Brady G  et al. Downregulation of RUNX1 by RUNX3 requires the RUNX3 VWRPY sequence and is essential for Epstein-Barr virus-driven B-cell proliferation. J Virol 83:6909-16 (2009). Read more (PubMed: 19403666) »

See all 2 Publications for this product

Product Wall

The immunogen is from the C-terminal region of BCMA, so the antibody binds the intracellular domain.

Thank you for contacting us.
This product has not been tested in mouse samples but it is unlikely to react, as the immunogen has very low homology with mouse.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"