功能Potent inhibitor of cell death. Inhibits activation of caspases (By similarity). Appears to regulate cell death by blocking the voltage-dependent anion channnel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Isoform Bcl-X(S) promotes apoptosis.
组织特异性Bcl-X(S) is expressed at high levels in cells that undergo a high rate of turnover, such as developing lymphocytes. In contrast, Bcl-X(L) is found in tissues containing long-lived postmitotic cells, such as adult brain.
序列相似性Belongs to the Bcl-2 family.
结构域The BH4 motif is required for anti-apoptotic activity. The BH1 and BH2 motifs are required for both heterodimerization with other Bcl-2 family members and for repression of cell death.
翻译后修饰Proteolytically cleaved by caspases during apoptosis. The cleaved protein, lacking the BH4 motif, has pro-apoptotic activity.
细胞定位Mitochondrion membrane. Nucleus membrane. Mitochondrial membranes and perinuclear envelope.
Protein phosphatase 1 regulatory subunit 52 antibody
Anti-Bcl-XL antibody 图像
Western blot - Anti-Bcl-XL antibody (ab59349)
All lanes : Anti-Bcl-XL antibody (ab59349) at 1/500 dilution
Lane 1 : Extracts from 293 cells, treated
with UV (30mins) with no immunizing peptide Lane 2 : Extracts from 293 cells, treated
with UV (30mins) with immunizing peptide
Predicted band size : 26 kDa
Anti-Bcl-XL antibody (ab59349)
ab59349, at a 1/50 dilution, staining human Bcl-XL in lung carcinoma, using Immunohistochemistry, Paraffin embedded tissue, in the absence (left image) and presence of the immunizing peptide (right image).
ab59349, at a 1/50 dilution, staining human Bcl2L1 in lung carcinoma, using Immunohistochemistry, Paraffin embedded tissue, in the absence (left image) and presence of the immunizing peptide (right image).
Anti-Bcl-XL antibody (ab59349)参考文献
has not yet been referenced specifically in any publications.