概述

  • 产品名称Anti-Bcl x抗体
    参阅全部 Bcl x 一抗
  • 描述
    兔多克隆抗体to Bcl x
  • 特异性ab125288 recognizes Bcl x (short form and long form).
  • 经测试应用适用于: WB, IP, ELISA, IHC-Pmore details
  • 种属反应性
    与反应: Mouse, Human
  • 免疫原

    Synthetic peptide corresponding to a region of Human Bcl x. This sequence is identical in Human and Mouse.

  • 阳性对照
    • Raji whole cell lysate; Human Hodgkin’s lymphoma tissue

性能

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应用

Our Abpromise guarantee covers the use of ab125288 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 0.1 - 1 µg/ml. Detects a band of approximately 27 kDa (predicted molecular weight: 26 kDa).
IP Use a concentration of 2 - 5 µg/ml.
ELISA Use a concentration of 0.01 - 0.1 µg/ml.
IHC-P Use a concentration of 2 - 5 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

靶标

  • 相关性Bcl x is a member of the Bcl 2 family of proteins, which function as regulators of apoptosis. It may provide neuroprotection against ischemic brian injury. Bcl x has two isoforms, Bcl xl (long) a 241 amino acid protein and Bcl xs (short) a 178 amino acid protein lacking a 63 amino acid domain that is well conserved among members of the Bcl2 family. Isoform Bcl-X(L) anti-apoptotic activity is inhibited by association with SIVA isoform 1. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage-dependent anion channnel (VDAC) by binding to it and preventing the release of the caspase activator, cytochrome c, from the mitochondrial membrane. The Bcl-X(S) isoform promotes apoptosis.
  • 细胞定位Mitochondrion membrane; Single-pass membrane protein. Nucleus membrane; Single-pass membrane protein; Cytoplasmic side. Note: Mitochondrial membranes and perinuclear envelope. Cytoskeleton
  • 数据库链接
  • 别名
    • Apoptosis regulator Bcl X antibody
    • Bcl 2 like 1 antibody
    • Bcl 2 like 1 protein antibody
    • Bcl xL antibody
    • BCL XL/S antibody
    • Bcl xS antibody
    • Bcl2 like1 antibody
    • BCL2-related gene antibody
    • BCL2-related protein, long isoform, included; BCLXL, included antibody
    • BCL2-related protein, short isoform, included; BCLXS, included antibody
    • BCL2L antibody
    • BCL2L1 antibody
    • Bclx antibody
    • DKFZp781P2092 antibody
    • MGC113803 antibody
    • MGC99998 antibody
    see all

Anti-Bcl x antibody 图像

  • ab125288, at 1/25 dilution, staining Bcl x in formalin-fixed, paraffin-embedded Human Hodgkin's lymphoma tissue by Immunohistochemistry.

Anti-Bcl x antibody (ab125288)参考文献

ab125288 has not yet been referenced specifically in any publications.

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