Anti-BCAR1抗体[EPR1850(2)] (ab108320)


  • 产品名称Anti-BCAR1抗体[EPR1850(2)]
    参阅全部 BCAR1 一抗
  • 描述
    兔单克隆抗体[EPR1850(2)] to BCAR1
  • 经测试应用适用于: WBmore details
    不适用于: Flow Cyt,ICC,IHC-P or IP
  • 种属反应性
    与反应: Mouse, Rat, Human
  • 免疫原

    A synthetic peptide corresponding to residues from Human BCAR1

  • 阳性对照
    • HeLa, T47-D, A431, C6, Raw264.7, PC12, and NIH 3T3 cell lysates
  • 常规说明

    This product is a recombinant rabbit monoclonal antibody.

    Produced using Abcam’s RabMAb® technology. RabMAb® technology is covered by the following U.S. Patents, No. 5,675,063 and/or 7,429,487.



Our Abpromise guarantee covers the use of ab108320 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/1000 - 1/10000. Predicted molecular weight: 93 kDa.
  • 应用说明Is unsuitable for Flow Cyt,ICC,IHC-P or IP.
  • 靶标

    • 功能Docking protein which plays a central coordinating role for tyrosine kinase-based signaling related to cell adhesion. Implicated in induction of cell migration. Overexpression confers antiestrogen resistance on breast cancer cells.
    • 组织特异性Widely expressed with an abundant expression in the testis. Low level of expression seen in the liver, thymus, and peripheral blood leukocytes. The protein has been detected in a B-cell line.
    • 序列相似性Belongs to the CAS family.
      Contains 1 SH3 domain.
    • 结构域Contains a central domain (substrate domain) containing multiple potential SH2-binding sites and a C-terminal domain containing a divergent helix-loop-helix (HLH) motif. The SH2-binding sites putatively bind CRK, NCK and ABL1 SH2 domains. The HLH motif is absolutely required for the induction of pseudohyphal growth in yeast and mediates heterodimerization with NEDD9.
      A serine-rich region promotes activation of the serum response element (SRE).
      The SH3 domain is necessary for the localization of the protein to focal adhesions and interacts with one proline-rich region of PTK2/FAK11.
    • 翻译后修饰PTK2/FAK1 activation mediates phosphorylation at the YDYVHL motif; phosphorylation is most likely catalyzed by SRC family members. SRC-family kinases are recruited to the phosphorylated sites and can phosphorylate other tyrosine residues. Tyrosine phosphorylation is triggered by integrin-mediated adhesion of cells to the extracellular matrix.
      Dephosphorylated by PTPN14 at Tyr-128.
    • 细胞定位Cell junction, focal adhesion. Cytoplasm. Unphosphorylated form localizes in the cytoplasm and can move to the membrane upon tyrosine phosphorylation.
    • Information by UniProt
    • 数据库链接
    • 别名
      • BCAR 1 antibody
      • Bcar1 antibody
      • BCAR1_HUMAN antibody
      • Breast cancer anti estrogen resistance 1 antibody
      • Breast cancer anti estrogen resistance 1 protein antibody
      • Breast cancer anti-estrogen resistance protein 1 antibody
      • CAS antibody
      • Cas scaffolding protein family member 1 antibody
      • CAS1 antibody
      • Cass1 antibody
      • Crk associated substrate antibody
      • Crk associated substrate p130Cas antibody
      • CRK-associated substrate antibody
      • CRKAS antibody
      • FLJ12176 antibody
      • FLJ45059 antibody
      • p130cas antibody
      see all

    Anti-BCAR1 antibody [EPR1850(2)] 图像

    • All lanes : Anti-BCAR1 antibody [EPR1850(2)] (ab108320) at 1/1000 dilution

      Lane 1 : HeLa cell lysate
      Lane 2 : T47-D cell lysate
      Lane 3 : A431 cell lysate
      Lane 4 : C6 cell lysate
      Lane 5 : Raw264.7 cell lysate
      Lane 6 : PC12 cell lysate
      Lane 7 : NIH 3T3 cell lysate

      Lysates/proteins at 10 µg per lane.

      Predicted band size : 93 kDa

    Anti-BCAR1 antibody [EPR1850(2)] (ab108320)参考文献

    ab108320 has not yet been referenced specifically in any publications.

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