RabMAb

Anti-Bax抗体[SP47], prediluted (ab81084)

概述

  • 产品名称Anti-Bax抗体[SP47], prediluted
    参阅全部 Bax 一抗
  • 描述
    兔单克隆抗体[SP47] to Bax, prediluted
  • 经测试应用适用于: IHC-Pmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide corresponding to Human Bax (internal sequence).
    Database link: Q07812

  • 阳性对照
    • Human breast, cervix, esophagus, prostate, skin, tonsil normal tissue. Skin and lung squamous cell carcinoma, Hodgkin's lymphoma.

性能

应用

Our Abpromise guarantee covers the use of ab81084 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P 1/1. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

靶标

  • 功能Accelerates programmed cell death by binding to, and antagonizing the apoptosis repressor BCL2 or its adenovirus homolog E1B 19k protein. Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis.
  • 组织特异性Expressed in a wide variety of tissues. Isoform Psi is found in glial tumors. Isoform Alpha is expressed in spleen, breast, ovary, testis, colon and brain, and at low levels in skin and lung. Isoform Sigma is expressed in spleen, breast, ovary, testis, lung, colon, brain and at low levels in skin. Isoform Alpha and isoform Sigma are expressed in pro-myelocytic leukemia, histiocytic lymphoma, Burkitt's lymphoma, T-cell lymphoma, lymphoblastic leukemia, breast adenocarcinoma, ovary adenocarcinoma, prostate carcinoma, prostate adenocarcinoma, lung carcinoma, epidermoid carcinoma, small cell lung carcinoma and colon adenocarcinoma cell lines.
  • 序列相似性Belongs to the Bcl-2 family.
  • 结构域Intact BH3 motif is required by BIK, BID, BAK, BAD and BAX for their pro-apoptotic activity and for their interaction with anti-apoptotic members of the Bcl-2 family.
  • 细胞定位Cytoplasm and Mitochondrion membrane. Cytoplasm. Colocalizes with 14-3-3 proteins in the cytoplasm. Under stress conditions, undergoes a conformation change that causes release from JNK-phosphorylated 14-3-3 proteins and translocation to the mitochondrion membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Apoptosis regulator BAX antibody
    • BAX antibody
    • Bax-protein antibody
    • BAX_HUMAN antibody
    • BAXA antibody
    • Baxdelta2G9 antibody
    • Baxdelta2G9omega antibody
    • Baxdelta2omega antibody
    • Bcl-2-like protein 4 antibody
    • BCL2 associated X protein antibody
    • BCL2 associated X protein omega antibody
    • BCL2 associated X protein transcript variant delta2 antibody
    • Bcl2-L-4 antibody
    • BCL2L4 antibody
    • membrane isoform alpha antibody
    see all

Anti-Bax antibody [SP47], prediluted 图像

  • Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human esophagus tissue staining Bax with ab81084, pre-diluted.

  • Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human prostate tissue staining Bax with ab81084, pre-diluted.

  • Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human breast tissue staining Bax with ab81084, pre-diluted.

  • Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human breast tissue staining Bax with ab81084, pre-diluted.

  • Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human cervix tissue staining Bax with ab81084, pre-diluted.

  • Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human skin tissue staining Bax with ab81084, pre-diluted.

  • Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human tonsil tissue staining Bax with ab81084, pre-diluted.

  • Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human skin squamous cell carcinoma tissue staining Bax with ab81084, pre-diluted.

  • Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human lung squamous cell carcinoma tissue staining Bax with ab81084, pre-diluted.

  • Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human Hodgkin's lymphoma tissue staining Bax with ab81084, pre-diluted.

Anti-Bax antibody [SP47], prediluted (ab81084)参考文献

ab81084 has not yet been referenced specifically in any publications.

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