Anti-BATF抗体(ab56685)

概述

  • 产品名称Anti-BATF抗体
    参阅全部 BATF 一抗
  • 描述
    小鼠单克隆抗体to BATF
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Recombinant fragment: EKNRIAAQKS RQRQTQKADT LHLESEDLEK QNAALRKEIK QLTEELKYFT SVLNSHEPLC SVLAASTPSP PEVVYSAHAF HQPHVSSPRF QP, corresponding to amino acids 34-126 of Human BATF

性能

应用

Our Abpromise guarantee covers the use of ab56685 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB
  • 应用说明WB: Use at a concentration of 1-5 µg/ml.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能AP-1 family transcription factor that controls the differentiation of lineage-specific cells in the immune system: specifically mediates the differentiation of T-helper 17 cells (Th17), follicular T-helper cells (TfH), CD8(+) dendritic cells and class-switch recombination (CSR) in B-cells. Acts via the formation of a heterodimer with JUNB that recognizes and binds DNA sequence 5'-TGA[CG]TCA-3'. The BATF-JUNB heterodimer also forms a complex with IRF4 (or IRF8) in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA-3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF4 (or IRF8) and activation of genes. Controls differentiation of T-helper cells producing interleukin-17 (Th17 cells) by binding to Th17-associated gene promoters: regulates expression of the transcription factor RORC itself and RORC target genes such as IL17 (IL17A or IL17B). Also involved in differentiation of follicular T-helper cells (TfH) by directing expression of BCL6 and MAF. In B-cells, involved in class-switch recombination (CSR) by controlling the expression of both AICDA and of germline transcripts of the intervening heavy-chain region and constant heavy-chain region (I(H)-C(H)). Following infection, can participate in CD8(+) dendritic cell differentiation via interaction with IRF4 and IRF8 to mediate cooperative gene activation. Regulates effector CD8(+) T-cell differentiation by regulating expression of SIRT1. Following DNA damage, part of a differentiation checkpoint that limits self-renewal of hematopoietic stem cells (HSCs): up-regulated by STAT3, leading to differentiation of HSCs, thereby restricting self-renewal of HSCs.
    • 组织特异性Expressed at highest levels in lung, and at lower levels in placenta, liver, kidney, spleen, and peripheral blood. Detected in SW480 colorectal cancer cell line and several hematopoietic tumor cell lines, including Raji Burkitt's lymphoma. Strongly expressed in mature B- and T-lymphocytes. Also expressed in moderate levels in lymph node and appendix and at low levels in thymus and bone marrow (PubMed:10777209).
    • 序列相似性Belongs to the bZIP family.
      Contains 1 bZIP (basic-leucine zipper) domain.
    • 翻译后修饰Phosphorylated on serine and threonine residues and at least one tyrosine residue. Phosphorylation at Ser-43 inhibit DNA binding activity and transforms it as a negative regulator of AP-1 mediated transcription.
      Phosphorylated.
    • 细胞定位Nucleus. Cytoplasm. Present in the nucleus and cytoplasm, but shows increased nuclear translocation after activation of T-cells.
    • Information by UniProt
    • 数据库链接
    • 别名
      • Activating transcription factor B antibody
      • B ATF antibody
      • B-ATF antibody
      • B-cell-activating transcription factor antibody
      • Basic leucine zipper transcription factor like antibody
      • Basic leucine zipper transcriptional factor ATF like antibody
      • Basic leucine zipper transcriptional factor ATF-like antibody
      • Batf antibody
      • BATF_HUMAN antibody
      • BATF1 antibody
      • SF HT activated gene 2 protein antibody
      • SF-HT-activated gene 2 protein antibody
      • SFA 2 antibody
      • SFA-2 antibody
      • SFA2 antibody
      see all

    Anti-BATF antibody 图像



    • Predicted band size : 14 kDa
      BATF antibody (ab56685) at 1ug/lane + HeLa cell lysate at 25ug/lane.

    Anti-BATF antibody (ab56685)参考文献

    ab56685 has not yet been referenced specifically in any publications.

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