Anti-BAP1抗体- C-terminal (ab71642)

概述

  • 产品名称Anti-BAP1抗体- C-terminal
    参阅全部 BAP1 一抗
  • 描述
    兔多克隆抗体to BAP1 - C-terminal
  • 经测试应用适用于: ELISA, WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide within Human BAP1 aa 699-729 (C terminal) conjugated to Keyhole Limpet Haemocyanin (KLH). The exact sequence is proprietary.

  • 阳性对照
    • SK-BR-3 cell lysate.

性能

应用

Our Abpromise guarantee covers the use of ab71642 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ELISA 1/1000.
WB 1/100 - 1/500. Detects a band of approximately 81 kDa (predicted molecular weight: 81 kDa).

靶标

  • 功能Deubiquitinating enzyme that plays a key role in chromatin by mediating deubiquitination of histone H2A and HCFC1. Catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1). Does not deubiquitinate monoubiquitinated histone H2B. Acts as a regulator of cell growth by mediating deubiquitination of HCFC1 N-terminal and C-terminal chains, with some specificity toward 'Lys-48'-linked polyubiquitin chains compared to 'Lys-63'-linked polyubiquitin chains. Deubiquitination of HCFC1 does not lead to increase stability of HCFC1. Interferes with the BRCA1 and BARD1 heterodimer activity by inhibiting their ability to mediate ubiquitination and autoubiquitination. It however does not mediate deubiquitination of BRCA1 and BARD1. Acts as a tumor suppressor.
  • 组织特异性Highly expressed in testis, placenta and ovary. Expressed in breast.
  • 序列相似性Belongs to the peptidase C12 family. BAP1 subfamily.
  • 翻译后修饰Phosphorylated upon DNA damage, probably by ATM or ATR.
  • 细胞定位Cytoplasm. Nucleus. Mainly nuclear. Binds to chromatin.
  • Information by UniProt
  • 数据库链接
  • 别名
    • BAP 1 antibody
    • Bap1 antibody
    • BAP1_HUMAN antibody
    • BRCA 1 associated protein 1 antibody
    • BRCA1 associated protein 1 antibody
    • BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase) antibody
    • BRCA1-associated protein 1 antibody
    • Cerebral protein 13 antibody
    • Cerebral protein 6 antibody
    • DKFZp686N04275 antibody
    • FLJ35406 antibody
    • FLJ37180 antibody
    • HUCEP 13 antibody
    • Hucep 6 antibody
    • HUCEP13 antibody
    • Hucep6 antibody
    • KIAA0272 antibody
    • TPDS antibody
    • Ubiquitin carboxy terminal hydrolase antibody
    • Ubiquitin carboxyl terminal hydrolase BAP 1 antibody
    • Ubiquitin carboxyl terminal hydrolase BAP1 antibody
    • Ubiquitin carboxyl-terminal hydrolase BAP1 antibody
    • UCHL2 antibody
    see all

Anti-BAP1 antibody - C-terminal 图像

  • Anti-BAP1 antibody - C-terminal (ab71642) at 1/100 dilution + SK-BR-3 cell lysate at 12.5 µg

    Predicted band size : 81 kDa
    Observed band size : 81 kDa
    Additional bands at : 30 kDa,60 kDa. We are unsure as to the identity of these extra bands.

Anti-BAP1 antibody - C-terminal (ab71642)参考文献

ab71642 has not yet been referenced specifically in any publications.

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